PMID- 18580852
OWN - NLM
STAT- MEDLINE
DCOM- 20080908
LR  - 20220310
IS  - 0172-780X (Print)
IS  - 0172-780X (Linking)
VI  - 29
IP  - 3
DP  - 2008 Jun
TI  - Clinical and molecular-genetic markers of ADHD in children.
PG  - 320-7
AB  - OBJECTIVES: The objective was to make a contribution to deepening the knowledge 
      of the etiopathogenesis of ADHD. DESIGN: In an association study design, an 
      analysis of polymorphisms of selected genes was conducted in 119 hyperkinetic 
      boys and a control group of boys, aged 7-13. Furthermore several psychologically 
      determined subgroups were identified. A connection between psychological 
      functions (endophenotypes) and genes were looked for. RESULTS: There was a 
      statistically significant difference found in allelic and genotype frequencies of 
      the TaqI A polymorphism of the DRD2 gene. The frequency of the allele A1 in 
      hyperkinetic boys and the control subjects was 0.26 and 0.15, respectively 
      (p<0.003). A statistically significant occurrence of atypical genotypes (8/10, 
      7/10 and 10/11) of the DAT1 gene was also found in hyperkinetic boys and a 
      connection between the M235 polymorphism of the angiotensinogene gene and the 
      positive family history of psychiatric illness was found in probands (p=0.031). 
      Significant correlations between the results of some neuropsychological tests and 
      genes for neuro-/immunomodulators (IL-6, TNF-alpha) and the gene for the 
      brain-derived neurotrophic factor (BDNF) were found. CONCLUSION: The study showed 
      a statistically significant prevalence of A1 allele of the DRD gene in the 
      hyperkinetic group. We also found a significantly higher incidence of atypical 
      DAT genotypes in the hyperkinetic group. Furthermore we found significant 
      connections with particular gene polymorphisms which may hypothetically represent 
      a neurodevelopmental risk factor in the etiopathogenesis of the disorder (IL-2, 
      IL-6, TNF-alpha, BDNF). We further found a connection of the M235 polymorphism of 
      the AGT (angiotensinogene) gene to positive family history of psychiatric illness 
      (p=0.031). As for cognitive characteristics, we identified three subtypes with 
      different cognitive performance profiles. This finding shows interindividual 
      variability of cognitive style in the group of hyperkinetic boys.
FAU - Drtilkova, Ivana
AU  - Drtilkova I
AD  - Department of Psychiatry, Faculty Hospital and Masaryk University Brno, Czech 
      Republic. idrtilkova@fnbrno.cz
FAU - Sery, Omar
AU  - Sery O
FAU - Theiner, Pavel
AU  - Theiner P
FAU - Uhrova, Alena
AU  - Uhrova A
FAU - Zackova, Marketa
AU  - Zackova M
FAU - Balastikova, Blanka
AU  - Balastikova B
FAU - Znojil, Vladimir
AU  - Znojil V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Neuro Endocrinol Lett
JT  - Neuro endocrinology letters
JID - 8008373
RN  - 0 (Biomarkers)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Genetic Markers)
RN  - 0 (Receptors, Dopamine D2)
RN  - 207ZZ9QZ49 (Methylphenidate)
SB  - IM
MH  - Adolescent
MH  - Attention/drug effects/physiology
MH  - Attention Deficit Disorder with Hyperactivity/epidemiology/*genetics/*metabolism
MH  - Biomarkers
MH  - Central Nervous System Stimulants/therapeutic use
MH  - Child
MH  - Czech Republic/epidemiology
MH  - Discrimination, Psychological/physiology
MH  - Form Perception/physiology
MH  - Genetic Markers
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Methylphenidate/therapeutic use
MH  - Neuropsychological Tests
MH  - Phenotype
MH  - Polymorphism, Genetic/genetics
MH  - Psychiatric Status Rating Scales
MH  - Psychomotor Performance/drug effects/physiology
MH  - Receptors, Dopamine D2/genetics
EDAT- 2008/06/27 09:00
MHDA- 2008/09/09 09:00
CRDT- 2008/06/27 09:00
PHST- 2008/05/13 00:00 [received]
PHST- 2008/05/28 00:00 [accepted]
PHST- 2008/06/27 09:00 [pubmed]
PHST- 2008/09/09 09:00 [medline]
PHST- 2008/06/27 09:00 [entrez]
AID - NEL290308A05 [pii]
PST - ppublish
SO  - Neuro Endocrinol Lett. 2008 Jun;29(3):320-7.