PMID- 18581603
OWN - NLM
STAT- MEDLINE
DCOM- 20081021
LR  - 20211020
IS  - 0513-5796 (Print)
IS  - 1976-2437 (Electronic)
IS  - 0513-5796 (Linking)
VI  - 49
IP  - 3
DP  - 2008 Jun 30
TI  - A case of multiple endocrine neoplasia type 1 combined with papillary thyroid 
      carcinoma.
PG  - 503-6
LID - 10.3349/ymj.2008.49.3.503 [doi]
AB  - This is the first report of papillary thyroid carcinoma combined with multiple 
      endocrine neoplasia type 1 (MEN1) in Korea. MEN1 is a hereditary disease 
      comprising neoplastic disorders such as pituitary, parathyroid and pancreatic 
      neuroendocrine tumor, such as gastrinoma. But papillary thyroid cancer was never 
      regarded as its component before in Korea. Herein we present a 39-year-old woman 
      who manifested typical features of MEN1 with a coincidental papillary thyroid 
      carcinoma. Although the family history of MEN1 was definite, her genetic analysis 
      of DNA had revealed no germline mutation in MEN1 gene locus. Unidentified culprit 
      gene unable us further genetic study to find LOH (loss of heterogeneity) in 
      11q13, the possible explanation of papillary thyroid carcinoma as a new component 
      of MEN1. As we have first experienced a case of MEN1 combined with papillary 
      thyroid carcinoma in Korea, we report it with the review of literature.
FAU - Kim, Hai-Jin
AU  - Kim HJ
AD  - Department of Endocrinology and Metabolism, Internal Medicine, Yonsei University 
      College of Medicine, Yongdong Severance Hospital, 612 Eonjuro, Gangnam-gu, Seoul 
      135-720, Korea.
FAU - Park, Jong-Suk
AU  - Park JS
FAU - Kim, Chul-Sik
AU  - Kim CS
FAU - Kang, Eun-Seok
AU  - Kang ES
FAU - Cha, Bong-Soo
AU  - Cha BS
FAU - Lim, Sung-Kil
AU  - Lim SK
FAU - Kim, Kyung-Rae
AU  - Kim KR
FAU - Lee, Hyun-Chul
AU  - Lee HC
FAU - Ahn, Chul-Woo
AU  - Ahn CW
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Korea (South)
TA  - Yonsei Med J
JT  - Yonsei medical journal
JID - 0414003
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Adult
MH  - Carcinoma, Papillary/genetics/*pathology
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/genetics/*pathology
MH  - Mutation
MH  - Proto-Oncogene Proteins/genetics
MH  - Thyroid Neoplasms/genetics/*pathology
PMC - PMC2615331
EDAT- 2008/06/27 09:00
MHDA- 2008/10/22 09:00
PMCR- 2008/06/30
CRDT- 2008/06/27 09:00
PHST- 2008/06/27 09:00 [pubmed]
PHST- 2008/10/22 09:00 [medline]
PHST- 2008/06/27 09:00 [entrez]
PHST- 2008/06/30 00:00 [pmc-release]
AID - 200806503 [pii]
AID - 10.3349/ymj.2008.49.3.503 [doi]
PST - ppublish
SO  - Yonsei Med J. 2008 Jun 30;49(3):503-6. doi: 10.3349/ymj.2008.49.3.503.