PMID- 18581863
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20161018
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 26
IP  - 2
DP  - 2008 Mar
TI  - [Determination of amphetamines in human urine using microwave extraction-gas 
      chromatography].
PG  - 254-8
AB  - A method has been developed for the determination of methamphetamine (MA), 
      3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethamphetamine (MDMA) 
      in human urine using microwave extraction-gas chromatography(GC). To improve the 
      extraction efficiency, experimental parameters of the extraction, including 
      extraction solvent and its amount, pH value of the urine sample, extraction time 
      and temperature were investigated. The optimal conditions were as follows: the pH 
      value of urine sample at pH 12, cyclohexane as extraction solvent, extraction at 
      40 degrees C for 10 min. The average recoveries of MA, MDA and MDMA with this 
      extraction method were 92.25%, 85.94% and 91.50%, the relative standard 
      deviations were 5.5%, 5.5% and 6.1%(n = 5), and the limits of detection were 10, 
      20 and 20 ng/mL, respectively. Using this method, MA, MDA and MDMA need not be 
      derivatized and can be separated from the matrix. The results indicate that the 
      developed method is rapid, accurate and sensitive, and can be used for the 
      simultaneous determination of MA, MDA and MDMA in urine samples.
FAU - Wang, Jifen
AU  - Wang J
AD  - Department of Criminal Science and Technology, Chinese People's Public Security 
      University, Beijing 100038, China. jifenjifen@tom.com
FAU - Sun, Hongfeng
AU  - Sun H
FAU - Ye, Nengsheng
AU  - Ye N
FAU - Gu, Xuexin
AU  - Gu X
FAU - Li, Wenjun
AU  - Li W
FAU - Li, Ying
AU  - Li Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Amphetamines)
RN  - 0 (Solvents)
SB  - IM
MH  - Amphetamines/*isolation & purification/*urine
MH  - Calibration
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Limit of Detection
MH  - *Microwaves
MH  - Reproducibility of Results
MH  - Solvents/chemistry
MH  - Substance Abuse Detection/*methods
MH  - Temperature
MH  - Time Factors
MH  - Urinalysis/*methods
EDAT- 2008/06/28 09:00
MHDA- 2010/06/18 06:00
CRDT- 2008/06/28 09:00
PHST- 2008/06/28 09:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
PHST- 2008/06/28 09:00 [entrez]
PST - ppublish
SO  - Se Pu. 2008 Mar;26(2):254-8.