PMID- 18581887
OWN - NLM
STAT- MEDLINE
DCOM- 20081222
LR  - 20221207
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 88
IP  - 6
DP  - 2008 Feb 5
TI  - [Association of variants in APPL1 gene with body fat and its distribution in 
      Chinese patients with type 2 diabetic mellitus].
PG  - 369-73
AB  - OBJECTIVE: To investigate the impact of single nucleotide polymorphisms (SNPs) in 
      APPL1 gene on body fat and its distribution. METHODS: 590 unrelated Shanghai 
      residents of Han nationality, including 358 subjects with normal glucose 
      tolerance (NGT) and 232 subjects with type 2 diabetes mellitus (T2DM), underwent 
      measurement of body mass index (BMI), waist circumference (W), hip circumference 
      (H), and femoral circumference (F). Peripheral blood samples were collected to 
      detect the blood sugar, blood lipids, fasting C - peptide (FCP), fasting insulin 
      (FINS), fasting plasma glucose (FGLU), total cholesterol (TC), and triglyceride 
      (TG) 0 and 120 minutes after glucose challenge. Polymerase chain 
      reaction-restriction fragment length polymorphism was used to detect the 2 SNPs 
      (rs3806622 and rs4640525). RESULTS: No differences in the frequencies of 
      rs3806622 and rs4640525 genotypes between the subjects with the BMI < 25 kg/m2 
      and those with the BMI > or = 25 kg/m2 either in the NGT group or T2DM group. The 
      G allele frequencies of the rs3806622 and rs4640525 genotypes in the T2DM 
      patients with longer W values were significantly higher than those in the 
      patients with shorter W value (OR = 2.26, 95% CI 1.05 - 4.86, and OR = 4.3, 95% 
      CI 1.21 - 14.09). The W values of the T2DM subjects with G alleles were 
      significantly higher than those of the T2DM subjects without G alleles after 
      adjustment of age, sex, and BMI (all P < 0.05). Stepwise regression analysis 
      showed that in addition to sex and BMI, rs4640525 was also an associated factor 
      of waist circumference (all P < 0.05). CONCLUSION: SNPs (rs3806622 and rs4640525) 
      in APPL1 gene are correlated with body fat distribution in T2DM.
FAU - Fang, Qi-Chen
AU  - Fang QC
AD  - Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Department of 
      Endocrinology and Metabolism, Sixth People's Hospital Affiliated to Shanghai 
      Jiaotong University, Shanghai 200233, China.
FAU - Jia, Wei-Ping
AU  - Jia WP
FAU - Gao, Fei
AU  - Gao F
FAU - Zhang, Rong
AU  - Zhang R
FAU - Hu, Cheng
AU  - Hu C
FAU - Wang, Cong-Rong
AU  - Wang CR
FAU - Wang, Chen
AU  - Wang C
FAU - Ma, Xiao-Jing
AU  - Ma XJ
FAU - Lu, Jun-Xi
AU  - Lu JX
FAU - Xu, Jing
AU  - Xu J
FAU - Chen, Hong-Zhuan
AU  - Chen HZ
FAU - Xiang, Kun-San
AU  - Xiang KS
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (APPL1 protein, human)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Blood Glucose)
RN  - 0 (Carrier Proteins)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Adipose Tissue/*metabolism
MH  - Aged
MH  - Alleles
MH  - Asian People/genetics
MH  - Blood Glucose/metabolism
MH  - Carrier Proteins/*genetics
MH  - China
MH  - Diabetes Mellitus, Type 2/ethnology/*genetics/*metabolism
MH  - Gene Frequency
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
EDAT- 2008/06/28 09:00
MHDA- 2008/12/23 09:00
CRDT- 2008/06/28 09:00
PHST- 2008/06/28 09:00 [pubmed]
PHST- 2008/12/23 09:00 [medline]
PHST- 2008/06/28 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2008 Feb 5;88(6):369-73.