PMID- 18582159
OWN - NLM
STAT- MEDLINE
DCOM- 20080808
LR  - 20080627
IS  - 0033-7587 (Print)
IS  - 0033-7587 (Linking)
VI  - 170
IP  - 1
DP  - 2008 Jul
TI  - RBE of X rays of different energies: a cytogenetic evaluation by FISH.
PG  - 93-100
LID - 10.1667/RR1280.1 [doi]
AB  - Mammography using 26-30 kVp X rays is routinely used in breast cancer screening. 
      Discussion about the radiation-related risk associated with this methodology is 
      ongoing. For radioprotection purposes, a quality factor of 1 has been assigned 
      for all photon energies. However, the relative biological effectiveness (RBE) 
      could increase as the photon energy decreases. Analyzing different biological 
      parameters, for 30 kVp X rays, RBE values from 1 to 8 have been estimated. In the 
      present study, a cytogenetic FISH evaluation of the RBE of 30, 80 and 120 kVp X 
      rays has been done. Blood samples were irradiated with 10 doses from 0.05 to 3 Gy 
      for each energy studied. The yields of translocations and dicentrics were 
      determined by fluorescence in situ hybridization (FISH) using whole chromosome 
      probes for chromosomes 1, 4 and 11 together with a pancentromeric probe. The 
      alpha coefficients of the dose-effect curves for dicentrics, minimum number of 
      breaks needed to produce exchange-type aberrations, and apparently simple 
      translocations were used to estimate the RBE. Using the curves obtained for 120 
      kVp as a reference, the RBE values for dicentrics were 1.08+/-0.43 and 
      1.73+/-0.59 for 80 and 30 kVp X rays, respectively; for minimum number of breaks 
      these values were 1.38+/-0.39 and 1.42+/-0.41, and for apparently simple 
      translocations they were 1.26+/-0.40 and 1.51+/-0.47, respectively. Moreover, the 
      induction of complex aberrations by these energies was compared. The percentage 
      of complex aberrations relative to total aberrations showed a significant 
      tendency to increase as X-ray energy decreased: 7.8+/-1.19, 9.8+/-1.6 and 
      14.1+/-1.9 for 120, 80 and 30 kVp, respectively (P<0.02).
FAU - Mestres, M
AU  - Mestres M
AD  - Unitat d'Antropologia Biologica, Departament de Biologia Animal, Biologia Vegetal 
      i Ecologia, Universitat Autonoma de Barcelona, E-08193, Bellaterra, Spain.
FAU - Caballin, M R
AU  - Caballin MR
FAU - Barrios, L
AU  - Barrios L
FAU - Ribas, M
AU  - Ribas M
FAU - Barquinero, J F
AU  - Barquinero JF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiat Res
JT  - Radiation research
JID - 0401245
SB  - IM
MH  - Adult
MH  - Cells, Cultured
MH  - Cytogenetics
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Male
MH  - Relative Biological Effectiveness
MH  - *X-Rays
EDAT- 2008/06/28 09:00
MHDA- 2008/08/09 09:00
CRDT- 2008/06/28 09:00
PHST- 2007/11/07 00:00 [received]
PHST- 2008/02/27 00:00 [accepted]
PHST- 2008/06/28 09:00 [pubmed]
PHST- 2008/08/09 09:00 [medline]
PHST- 2008/06/28 09:00 [entrez]
AID - RR1280 [pii]
AID - 10.1667/RR1280.1 [doi]
PST - ppublish
SO  - Radiat Res. 2008 Jul;170(1):93-100. doi: 10.1667/RR1280.1.