PMID- 18582515
OWN - NLM
STAT- MEDLINE
DCOM- 20081125
LR  - 20221207
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 69
IP  - 7
DP  - 2008 Jul
TI  - Human leukocyte antigen-A, -B, and -DRB1 haplotypes of cord blood units in the 
      Tzu Chi Taiwan Cord Blood Bank.
PG  - 430-6
LID - 10.1016/j.humimm.2008.05.012 [doi]
AB  - Cord blood (CB) is considered an alternative resource to bone marrow and 
      peripheral blood stem cells (PBSC) for allogeneic stem cell transplantation. In 
      this study, human leukocyte antigen (HLA)-A, -B, and -DRB1 high-resolution allele 
      types were analyzed from a total of 710 CB units in the Tzu Chi Taiwan Cord Blood 
      Bank. We observed 21 HLA-A alleles, 59 HLA-B alleles, and 28 HLA-DRB1 alleles, 
      whereas 19 unique alleles were present in the CB units of 2,023 individuals 
      selected for confirmatory testing in the Tzu Chi Taiwan Marrow Donor Registry 
      (TCTMDR). The allelic associations between the HLA-A and -B locus were stronger 
      than that of either the HLA-B and -DRB1 loci or the HLA-A and -DRB1 loci. The 
      most common haplotype of CB units in the general Taiwanese population was 
      A*3303-B*5801-DRB1*0301 (6.59%), followed by A*0207-B*4601-DRB1*0901 (3.47%) and 
      then A*1101-B*4001-DRB1*0901 (2.11%). Moreover, two haplotypes, 
      A*2402-B*5201-DRB1*1502 and A*0201-B*1301-DRB1*1202, existed uniquely in the CB 
      units but were not observed in the data of TCTMDR. Although the number of CB 
      units studied for high-resolution of HLA typing in the current study is small, we 
      believe our data should provide useful information to increase the chances of 
      obtaining acceptable HLA-A-, -B-, and -DRB1-matched CB units for patients.
FAU - Wen, Shu-Hui
AU  - Wen SH
AD  - Department of Public Health, College of Medicine, Buddhist Tzu-Chi University, 
      Hualien 970, Taiwan.
FAU - Lai, Meng-Jiun
AU  - Lai MJ
FAU - Yang, Kuo-Liang
AU  - Yang KL
LA  - eng
PT  - Journal Article
DEP - 20080626
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
RN  - 0 (HLA-DRB1*12:02 antigen)
SB  - IM
MH  - *Alleles
MH  - *Asian People
MH  - Blood Banks
MH  - Female
MH  - Fetal Blood/*immunology
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Pregnancy
MH  - Taiwan
EDAT- 2008/06/28 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/06/28 09:00
PHST- 2007/12/25 00:00 [received]
PHST- 2008/05/15 00:00 [revised]
PHST- 2008/05/27 00:00 [accepted]
PHST- 2008/06/28 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/06/28 09:00 [entrez]
AID - S0198-8859(08)00092-X [pii]
AID - 10.1016/j.humimm.2008.05.012 [doi]
PST - ppublish
SO  - Hum Immunol. 2008 Jul;69(7):430-6. doi: 10.1016/j.humimm.2008.05.012. Epub 2008 
      Jun 26.