PMID- 18582577
OWN - NLM
STAT- MEDLINE
DCOM- 20081003
LR  - 20080721
IS  - 0955-0674 (Print)
IS  - 0955-0674 (Linking)
VI  - 20
IP  - 4
DP  - 2008 Aug
TI  - Endosomal sorting of MHC class II determines antigen presentation by dendritic 
      cells.
PG  - 437-44
LID - 10.1016/j.ceb.2008.05.011 [doi]
AB  - Dendritic cells (DCs) initiate primary immune responses by presenting 
      pathogen-derived antigens in association with major histocompatibility Class II 
      molecules (MHC II) to T cells. In DCs, MHC II is constitutively synthesized and 
      loaded at endosomes with peptides from hydrolyzed endogenous proteins or 
      exogenously acquired antigens. Whether peptide loaded MHC II (MHC II-p) is 
      subsequently recruited to and stably expressed at the plasma membrane or degraded 
      in lysosomes is determined by the status of the DC. In immature DCs, MHC II-p is 
      ubiquitinated after peptide loading, driving its sorting to the luminal vesicles 
      of multivesicular bodies. These luminal vesicles, and the MHC II-p they carry, 
      are delivered to lysosomes for degradation. MHC II-p is inefficiently 
      ubiquitinated in DCs that are activated by pathogens or inflammatory stimuli, 
      thus allowing its transfer to and stable expression at the plasma membrane.
FAU - van Niel, Guillaume
AU  - van Niel G
AD  - Institut Curie, Centre National de la Recherche Scientifique-Unite Mixte de 
      Recherche 144, Paris 75248, France. Guillaume.van-Niel@Curie.fr
FAU - Wubbolts, Richard
AU  - Wubbolts R
FAU - Stoorvogel, Willem
AU  - Stoorvogel W
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20080705
PL  - England
TA  - Curr Opin Cell Biol
JT  - Current opinion in cell biology
JID - 8913428
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - Dendritic Cells/*immunology
MH  - Endocytosis
MH  - Endosomes/*metabolism
MH  - Histocompatibility Antigens Class II/*immunology
MH  - Humans
MH  - Inflammation/immunology
MH  - Ubiquitination
RF  - 54
EDAT- 2008/06/28 09:00
MHDA- 2008/10/04 09:00
CRDT- 2008/06/28 09:00
PHST- 2008/03/11 00:00 [received]
PHST- 2008/04/21 00:00 [revised]
PHST- 2008/05/29 00:00 [accepted]
PHST- 2008/06/28 09:00 [pubmed]
PHST- 2008/10/04 09:00 [medline]
PHST- 2008/06/28 09:00 [entrez]
AID - S0955-0674(08)00107-5 [pii]
AID - 10.1016/j.ceb.2008.05.011 [doi]
PST - ppublish
SO  - Curr Opin Cell Biol. 2008 Aug;20(4):437-44. doi: 10.1016/j.ceb.2008.05.011. Epub 
      2008 Jul 5.