PMID- 18582801
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20220408
IS  - 1557-3117 (Electronic)
IS  - 1053-2498 (Linking)
VI  - 27
IP  - 7
DP  - 2008 Jul
TI  - Predictive utility of the 6-minute walk distance on survival in patients awaiting 
      lung transplantation.
PG  - 729-34
LID - 10.1016/j.healun.2008.03.017 [doi]
AB  - BACKGROUND: The 6-minute walk distance (6MWD) is a widely used clinical indicator 
      of exercise capacity. Although used as part of the assessment process in 
      determining a candidate's suitability for lung transplantation (LT), the 
      literature describing the impact of the 6MWD in predicting survival on LT waiting 
      lists is limited. This study aimed to determine the hazard function associated 
      with the 6MWD, and its utility relative to other prognostic variables. METHODS: A 
      retrospective chart review was conducted on 163 patients who were listed for 
      single or double LT, and either survived to transplant or died while on the 
      waiting list. A Cox regression for survival analysis, stratified by diagnostic 
      group, was conducted utilizing the 6MWD, demographic variables and measures of 
      cardiopulmonary function. RESULTS: The 6MWD proved to be the only significant 
      covariate in the Cox regression for survival analysis (p < 0.001), with all other 
      variables eliminated as non-significant. Furthermore, there was a protective 
      effect for each unit increase in the 6MWD [Exp (B) = 0.994, 95% confidence 
      interval 0.990 to 0.997]. CONCLUSIONS: This research demonstrates that the 6MWD 
      is useful for stratifying patients on the LT waiting list by identifying those 
      patients with a significantly higher risk of mortality.
FAU - Tuppin, Michael Patrick
AU  - Tuppin MP
AD  - Queensland Heart and Lung Transplant Unit, Prince Charles Hospital, University of 
      Queensland, Brisbane, Queensland, Australia. mail@miketuppin.com
FAU - Paratz, Jennifer D
AU  - Paratz JD
FAU - Chang, Angela T
AU  - Chang AT
FAU - Seale, Helen E
AU  - Seale HE
FAU - Walsh, James R
AU  - Walsh JR
FAU - Kermeeen, Fiona D
AU  - Kermeeen FD
FAU - McNeil, Keith D
AU  - McNeil KD
FAU - Hopkins, Peter M
AU  - Hopkins PM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20080519
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the 
      International Society for Heart Transplantation
JID - 9102703
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - *Lung Transplantation
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Survival Analysis
MH  - Time Factors
MH  - *Waiting Lists
MH  - Walking/*physiology
EDAT- 2008/06/28 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/06/28 09:00
PHST- 2007/11/19 00:00 [received]
PHST- 2008/02/13 00:00 [revised]
PHST- 2008/03/27 00:00 [accepted]
PHST- 2008/06/28 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/06/28 09:00 [entrez]
AID - S1053-2498(08)00279-9 [pii]
AID - 10.1016/j.healun.2008.03.017 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2008 Jul;27(7):729-34. doi: 
      10.1016/j.healun.2008.03.017. Epub 2008 May 19.