PMID- 18583876
OWN - NLM
STAT- MEDLINE
DCOM- 20080918
LR  - 20211020
IS  - 1011-8934 (Print)
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Linking)
VI  - 23
IP  - 3
DP  - 2008 Jun
TI  - Prognostic significance of HER2 gene amplification according to stage of breast 
      cancer.
PG  - 414-20
LID - 10.3346/jkms.2008.23.3.414 [doi]
AB  - It is well known that the amplification of the HER2 gene is closely associated 
      with poor prognosis of breast cancer. However, there is controversy about the 
      clinical significance of HER2 according to lymph node status in breast cancer. 
      The aim of this study was to identify the differences in the prognostic 
      significance of HER2 gene amplification according to the stages of breast cancer. 
      We prepared a tissue array for fluorescence in situ hybridization (FISH) with 
      breast cancer specimens from the surgery in 1994 to 1999. Total 338 cases of 
      breast cancer were enrolled and the median follow-up period was 6.3 yr. The 
      detection rates of HER2 gene amplification were as follows: 10.3% in stage I, 
      22.3% in stage II, and 43.8% in stage III. On survival analyses HER2-positive 
      groups showed worse prognosis in stage III of breast cancer, but not in stage I 
      or II. Multivariate analyses with a Cox-regression model also revealed that HER2 
      amplification was an independent prognostic factor only in stage III breast 
      cancer. Regarding HER2 gene amplification as a prognostic factor of breast 
      cancer, the clinical significance of the gene was found to be confined to 
      advanced breast cancer.
FAU - Kim, Yong-Seok
AU  - Kim YS
AD  - Department of Surgery, College of Medicine, The Catholic University of Korea, 
      Seoul, Korea.
FAU - Won, Yong Sung
AU  - Won YS
FAU - Park, Kyung Shin
AU  - Park KS
FAU - Song, Byung Joo
AU  - Song BJ
FAU - Kim, Jeong Soo
AU  - Kim JS
FAU - Oh, Se Jeong
AU  - Oh SJ
FAU - Jeon, Hae Myung
AU  - Jeon HM
FAU - Jung, Sang Seol
AU  - Jung SS
FAU - Park, Woo-Chan
AU  - Park WC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/genetics
MH  - Breast Neoplasms/*genetics/mortality/*pathology
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Amplification
MH  - Genes, erbB-2/*genetics
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Proportional Hazards Models
PMC - PMC2526508
EDAT- 2008/06/28 09:00
MHDA- 2008/09/19 09:00
PMCR- 2008/06/01
CRDT- 2008/06/28 09:00
PHST- 2008/06/28 09:00 [pubmed]
PHST- 2008/09/19 09:00 [medline]
PHST- 2008/06/28 09:00 [entrez]
PHST- 2008/06/01 00:00 [pmc-release]
AID - 200806414 [pii]
AID - 10.3346/jkms.2008.23.3.414 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2008 Jun;23(3):414-20. doi: 10.3346/jkms.2008.23.3.414.