PMID- 18584562
OWN - NLM
STAT- MEDLINE
DCOM- 20080904
LR  - 20181201
IS  - 0882-0538 (Print)
IS  - 0882-0538 (Linking)
VI  - 23
IP  - 4
DP  - 2008 Jul-Aug
TI  - Effects of anti herpetic drugs on mice with herpetic epithelial keratitis after 
      reactivation of herpes simplex virus type 1.
PG  - 241-7
LID - 10.1080/08820530802111291 [doi]
AB  - To compare the efficacies of valacyclovir (VCV) and acyclovir (ACV) on murine 
      herpetic epithelial keratitis, mice inoculated with herpes simplex virus type 
      1(HSV-1) strain McKrae were divided into 6 treatment groups: oral VCV 50 mg/kg 
      and 100 mg/kg, oral ACV 50 mg/kg, ACV eye ointment (EO), ACV eye drops (ED), and 
      placebo. Keratitis scores showed that oral VCV 50 mg/kg, oral ACV, and ACV ED had 
      equivalent efficacies, while oral VCV 100 mg/kg was as efficacious as ACV EO 
      during acute infection. Each treatment group was further divided into the 
      stimulated group with HSV-1 reactivation by immunosuppressant drugs and 
      hyperthermia, and the non-stimulated group without reactivation. We assessed the 
      virus titers in tissues by plaque assay and HSV DNA copy number in the trigeminal 
      ganglia (TG) by real time polymerase chain reaction (PCR). Results showed that 
      the virus titers in the tissues were lowered after reactivation, and the oral VCV 
      group with reactivation had significantly reduced DNA copy number in the TG than 
      the same treatment group without reactivation. In conclusion, oral VCV is as 
      efficacious as ACV EO and significantly suppresses HSV-1 reactivation.
FAU - Itahashi, Motoki
AU  - Itahashi M
AD  - Department of Ophthalmology, Kinki University School of Medicine, Osaka-Sayama, 
      Japan.
FAU - Higaki, Shiro
AU  - Higaki S
FAU - Shimomura, Yoshikazu
AU  - Shimomura Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Semin Ophthalmol
JT  - Seminars in ophthalmology
JID - 8610759
RN  - 0 (Antiviral Agents)
RN  - 0 (DNA, Viral)
RN  - HG18B9YRS7 (Valine)
RN  - MZ1IW7Q79D (Valacyclovir)
RN  - X4HES1O11F (Acyclovir)
SB  - IM
MH  - Acyclovir/*analogs & derivatives/*therapeutic use
MH  - Animals
MH  - Antiviral Agents/*therapeutic use
MH  - DNA, Viral/genetics
MH  - Epithelium, Corneal/*virology
MH  - Female
MH  - Gene Dosage
MH  - Herpesvirus 1, Human/*physiology
MH  - Keratitis, Herpetic/*drug therapy/virology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Trigeminal Ganglion/virology
MH  - Valacyclovir
MH  - Valine/*analogs & derivatives/therapeutic use
MH  - Virus Activation/drug effects
EDAT- 2008/06/28 09:00
MHDA- 2008/09/05 09:00
CRDT- 2008/06/28 09:00
PHST- 2008/06/28 09:00 [pubmed]
PHST- 2008/09/05 09:00 [medline]
PHST- 2008/06/28 09:00 [entrez]
AID - 794513458 [pii]
AID - 10.1080/08820530802111291 [doi]
PST - ppublish
SO  - Semin Ophthalmol. 2008 Jul-Aug;23(4):241-7. doi: 10.1080/08820530802111291.