PMID- 18585018
OWN - NLM
STAT- MEDLINE
DCOM- 20081023
LR  - 20080901
IS  - 0940-2993 (Print)
IS  - 0940-2993 (Linking)
VI  - 60
IP  - 6
DP  - 2008 Sep
TI  - Expression of neurotrophic factors in human primary pterygeal tissue and 
      selective TNF-alpha-induced stimulation of ciliary neurotrophic factor in 
      pterygeal fibroblasts.
PG  - 513-20
LID - 10.1016/j.etp.2008.04.013 [doi]
AB  - Pterygium is a degenerative, fibrovascular and hyperplastic growth resulting from 
      a proliferative tissue actively growing from altered limbal stem cells at the 
      corneal-conjunctival junction. However, the pathogenesis of pterygium is still 
      unclear. The aim of this study was to determine the expression of neurotrophic 
      factors (nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), 
      ciliary neurotrophic factor (CNTF), and neurotrophin (NT)-3, NT-4/5) in pterygeal 
      tissue and to confirm whether tumor-necrosis factor-alpha (TNF-alpha) modulates 
      the expression of these neurotrophic factors in primary cultured pterygeal 
      fibroblasts. We looked for expression of these neurotrophic factors in surgically 
      excised pterygia and normal donor limbal tissues by immunohistochemistry and in 
      primary cultured pterygeal and normal subconjunctival Tenon's fibroblasts by 
      Western blot and reverse transcription-polymerase chain reaction (RT-PCR). 
      Expression of CNTF and NT-4/5 is increased in pterygeal tissues compared with 
      normal tissue, and production of CNTF is stimulated in pterygeal fibroblasts by 
      TNF-alpha but not in normal fibroblasts. This selective stimulation of CNTF in 
      pterygeal fibroblasts suggests that CNTF may play a role in the pathogenesis of 
      pterygium.
FAU - Hong, Samin
AU  - Hong S
AD  - Department of Ophthalmology, Institute of Vision Research, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Choi, Jin Young
AU  - Choi JY
FAU - Lee, Hyung Keun
AU  - Lee HK
FAU - Seong, Gong Je
AU  - Seong GJ
FAU - Seo, Kyoung Yul
AU  - Seo KY
FAU - Kim, Eung-Kweon
AU  - Kim EK
FAU - Byeon, Suk Ho
AU  - Byeon SH
LA  - eng
PT  - Journal Article
DEP - 20080626
PL  - Germany
TA  - Exp Toxicol Pathol
JT  - Experimental and toxicologic pathology : official journal of the Gesellschaft fur 
      Toxikologische Pathologie
JID - 9208920
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Ciliary Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Cells, Cultured
MH  - Ciliary Neurotrophic Factor/genetics/metabolism
MH  - Fibroblasts/drug effects/*metabolism/pathology
MH  - Gene Expression/drug effects
MH  - Humans
MH  - Limbus Corneae/cytology/drug effects/metabolism
MH  - Nerve Growth Factor/genetics/metabolism
MH  - Nerve Growth Factors/genetics/*metabolism
MH  - Pterygium/drug therapy/*metabolism/pathology
MH  - RNA, Messenger/metabolism
MH  - Recombinant Proteins/pharmacology
MH  - Tumor Necrosis Factor-alpha/*pharmacology
EDAT- 2008/07/01 09:00
MHDA- 2008/10/24 09:00
CRDT- 2008/07/01 09:00
PHST- 2008/03/10 00:00 [received]
PHST- 2008/04/11 00:00 [revised]
PHST- 2008/04/15 00:00 [accepted]
PHST- 2008/07/01 09:00 [pubmed]
PHST- 2008/10/24 09:00 [medline]
PHST- 2008/07/01 09:00 [entrez]
AID - S0940-2993(08)00085-7 [pii]
AID - 10.1016/j.etp.2008.04.013 [doi]
PST - ppublish
SO  - Exp Toxicol Pathol. 2008 Sep;60(6):513-20. doi: 10.1016/j.etp.2008.04.013. Epub 
      2008 Jun 26.