PMID- 1858512
OWN - NLM
STAT- MEDLINE
DCOM- 19910826
LR  - 20131121
IS  - 0001-6772 (Print)
IS  - 0001-6772 (Linking)
VI  - 141
IP  - 3
DP  - 1991 Mar
TI  - Stimulation of airway ciliary motility by immunologically activated canine 
      pulmonary macrophages: role of leukotrienes.
PG  - 415-20
AB  - To elucidate a possible interaction between alveolar macrophages and airway 
      epithelial cells in allergic conditions, we studied the effect of immunologically 
      stimulated macrophages on ciliary beat frequency (CBF) of cultured canine 
      tracheal epithelium by a photoelectric method. Administration of supernatants 
      from macrophages incubated with anti-dinitrophenyl (DNP) IgE antibody and 
      anti-dinitrophenyl-human serum albumin dose-dependently increased ciliary beat 
      frequency, the maximal increase from the baseline being 30.4 +/- 5.0% (mean +/- 
      SE, P less than 0.01), an effect that was accompanied by the release of 
      leukotriene (LT) C4 and leukotriene D4. This ciliostimulation was not affected by 
      pretreatment of macrophages with indomethacin but was inhibited by that with 
      nordihydroguaiaretic acid. Addition of FPL 55712 abolished the response of 
      ciliary beat frequency to the stimulated macrophages, and exogenously 
      administered leukotriene C4 and leukotriene D4 dose-dependently increased ciliary 
      beat frequency. These results suggest that macrophages increase respiratory 
      ciliary motility through the IgE-mediated release of leukotrienes and may 
      modulate mucociliary transport function in the airway.
FAU - Tamaoki, J
AU  - Tamaoki J
AD  - First Department of Medicine, Tokyo Women's Medical College, Japan.
FAU - Sakai, N
AU  - Sakai N
FAU - Kobayashi, K
AU  - Kobayashi K
FAU - Kanemura, T
AU  - Kanemura T
FAU - Takizawa, T
AU  - Takizawa T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Acta Physiol Scand
JT  - Acta physiologica Scandinavica
JID - 0370362
RN  - 0 (Arachidonic Acids)
RN  - 0 (Leukotrienes)
RN  - 0 (SRS-A)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 7BO8G1BYQU (Masoprocol)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Animals
MH  - Arachidonic Acids/metabolism
MH  - Cilia/physiology
MH  - Dogs
MH  - Immunoglobulin E/immunology
MH  - Indomethacin/pharmacology
MH  - Leukotrienes/*physiology
MH  - Macrophage Activation
MH  - Macrophages/immunology/*physiology
MH  - Masoprocol/pharmacology
MH  - Pulmonary Alveoli/immunology/*physiology
MH  - SRS-A/physiology
EDAT- 1991/03/01 00:00
MHDA- 1991/03/01 00:01
CRDT- 1991/03/01 00:00
PHST- 1991/03/01 00:00 [pubmed]
PHST- 1991/03/01 00:01 [medline]
PHST- 1991/03/01 00:00 [entrez]
AID - 10.1111/j.1748-1716.1991.tb09099.x [doi]
PST - ppublish
SO  - Acta Physiol Scand. 1991 Mar;141(3):415-20. doi: 
      10.1111/j.1748-1716.1991.tb09099.x.