PMID- 18585458
OWN - NLM
STAT- MEDLINE
DCOM- 20090106
LR  - 20101118
IS  - 0952-7915 (Print)
IS  - 0952-7915 (Linking)
VI  - 20
IP  - 4
DP  - 2008 Aug
TI  - Nucleic acid sensing Toll-like receptors in dendritic cells.
PG  - 408-13
LID - 10.1016/j.coi.2008.06.003 [doi]
AB  - Dendritic cells (DCs) are crucial immune cells detecting microorganisms and 
      linking innate and adaptive immunity. Various microorganism-derived components, 
      including lipids, proteins, or nucleic acids, activate DCs through various 
      pattern recognition receptors (PRRs). PRRs can principally detect 
      non-self-components, but nucleic acid components are peculiar in that 
      self-derived nucleic acids can also stimulate PRRs. Thus, nucleic-acid-sensing 
      PRRs can potentially cause autoimmune responses. This potential danger comes out 
      in certain situations, and especially nucleic-acid-induced type I interferon 
      production contributes to the pathogenesis of autoimmune disorders. Here we 
      review how DCs detect and respond to nucleic acid adjuvants and how self-derived 
      nucleic acids can cause autoimmunity. Clarifying such mechanisms should 
      contribute to the development of therapeutic manipulation for autoimmune 
      diseases.
FAU - Hoshino, Katsuaki
AU  - Hoshino K
AD  - Laboratory for Host Defense, Research Center for Allergy and Immunology, RIKEN, 
      1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan.
FAU - Kaisho, Tsuneyasu
AU  - Kaisho T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080701
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - 0 (Interferon Type I)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (NF-kappa B)
RN  - 0 (Nucleic Acids)
RN  - 0 (Toll-Like Receptors)
RN  - 0 (Tumor Necrosis Factor Receptor-Associated Peptides and Proteins)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.11.10 (I-kappa B Kinase)
SB  - IM
MH  - Animals
MH  - Autoimmunity
MH  - Dendritic Cells/*immunology/metabolism
MH  - Humans
MH  - I-kappa B Kinase/metabolism
MH  - Interferon Type I/immunology/*metabolism
MH  - Myeloid Differentiation Factor 88/metabolism
MH  - NF-kappa B/metabolism
MH  - Nucleic Acids/*immunology/metabolism
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Toll-Like Receptors/*immunology/metabolism
MH  - Tumor Necrosis Factor Receptor-Associated Peptides and Proteins/metabolism
RF  - 50
EDAT- 2008/07/01 09:00
MHDA- 2009/01/07 09:00
CRDT- 2008/07/01 09:00
PHST- 2008/05/29 00:00 [received]
PHST- 2008/06/02 00:00 [accepted]
PHST- 2008/07/01 09:00 [pubmed]
PHST- 2009/01/07 09:00 [medline]
PHST- 2008/07/01 09:00 [entrez]
AID - S0952-7915(08)00094-0 [pii]
AID - 10.1016/j.coi.2008.06.003 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2008 Aug;20(4):408-13. doi: 10.1016/j.coi.2008.06.003. Epub 
      2008 Jul 1.