PMID- 18585782
OWN - NLM
STAT- MEDLINE
DCOM- 20090325
LR  - 20211028
IS  - 0149-7634 (Print)
IS  - 0149-7634 (Linking)
VI  - 33
IP  - 2
DP  - 2009 Feb
TI  - Is neurogenic hypertension related to vascular inflammation of the brainstem?
PG  - 89-94
LID - 10.1016/j.neubiorev.2008.05.020 [doi]
AB  - Essential hypertension is idiopathic although it is accepted as a complex 
      polygenic trait with underlying genetic components, which remain unknown. Our 
      supposition is that hypertension involves activation of the sympathetic nervous 
      system. One pivotal region controlling arterial pressure set point is nucleus 
      tractus solitarii (NTS). We recently identified that pro-inflammatory molecules, 
      such as junctional adhesion molecule-1 (JAM-1), were over expressed in 
      endothelial cells of the microvasculature supplying the NTS in an animal model of 
      human hypertension (the spontaneously hypertensive rat) compared to normotensive 
      Wistar-Kyoto rats (WKY). Over expression of JAM-1 in NTS of WKY rats was 
      pro-hypertensive and induced leukocyte adherence to the microvasculature. Since 
      leukocyte adhesion causes cytokine release, we found expression of monocyte 
      chemoattractant protein-1 (MCP-1) was higher in the NTS of SHR while 
      inter-leukin-6 (IL-6) was lower compared to the WKY rat. Inflammation of the 
      brainstem microvasculature may increase vascular resistance within the brainstem. 
      High brainstem vascular resistance and its inflammation may release pathological 
      paracrine signaling molecules affecting central neural cardiovascular activity 
      conducive to neurogenic hypertension.
FAU - Paton, Julian F R
AU  - Paton JF
AD  - Department of Physiology & Pharmacology, Bristol Heart Institute, School of 
      Medical Sciences, University of Bristol, Bristol BS8 1TD, UK. 
      Julian.f.r.paton@Bristol.ac.uk
FAU - Waki, Hidefumi
AU  - Waki H
LA  - eng
GR  - RG/07/006/23634/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080523
PL  - United States
TA  - Neurosci Biobehav Rev
JT  - Neuroscience and biobehavioral reviews
JID - 7806090
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Chemokine CCL2)
RN  - 0 (F11r protein, rat)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Animals
MH  - Brain Stem/*metabolism
MH  - Cell Adhesion Molecules/metabolism
MH  - Chemokine CCL2/metabolism
MH  - Endothelial Cells/metabolism
MH  - Hypertension/etiology/*metabolism
MH  - Inflammation/*complications/metabolism
MH  - Interleukin-6/*metabolism
MH  - Microvessels/*metabolism/pathology
MH  - Solitary Nucleus/cytology/*metabolism
RF  - 83
EDAT- 2008/07/01 09:00
MHDA- 2009/03/26 09:00
CRDT- 2008/07/01 09:00
PHST- 2008/02/11 00:00 [received]
PHST- 2008/05/07 00:00 [revised]
PHST- 2008/05/15 00:00 [accepted]
PHST- 2008/07/01 09:00 [pubmed]
PHST- 2009/03/26 09:00 [medline]
PHST- 2008/07/01 09:00 [entrez]
AID - S0149-7634(08)00087-0 [pii]
AID - 10.1016/j.neubiorev.2008.05.020 [doi]
PST - ppublish
SO  - Neurosci Biobehav Rev. 2009 Feb;33(2):89-94. doi: 
      10.1016/j.neubiorev.2008.05.020. Epub 2008 May 23.