PMID- 18586064
OWN - NLM
STAT- MEDLINE
DCOM- 20090227
LR  - 20151119
IS  - 1096-0295 (Electronic)
IS  - 0273-2300 (Linking)
VI  - 52
IP  - 3
DP  - 2008 Dec
TI  - On the skin sensitisation potential of rosin and oxidised rosin.
PG  - 257-63
LID - 10.1016/j.yrtph.2008.05.013 [doi]
AB  - In the EU rosin is classified as a skin sensitiser, apparently on the basis of 
      its oxidation to sensitising agents. Rosin (gum, tall oil or wood) is not a skin 
      sensitiser when examined in the guinea pig maximisation test (GPMT). Oxidised 
      rosins are sensitisers in the GPMT. Oxidised gum rosin was further tested in the 
      mouse local lymph node assay (LLNA) and the Buehler test, but is not a sensitiser 
      in either of these tests. Further, the outcome of the LLNA can be used to assess 
      the potency of oxidised rosin as an inducing agent in humans, and oxidised rosin 
      is, at most, a weak sensitiser in this test. Thus, oxidised rosin is not a potent 
      inducing agent for skin sensitisation unless the dermal barrier is bypassed 
      and/or there is deliberate use of Freund's Complete Adjuvant to induce greater 
      susceptibility. The material used for human patch testing ('colophony') is in 
      oxidised form. A re-examination of epidemiological studies suggests that patients 
      in dermatological clinics show higher response rates than do the general 
      population or those occupationally exposed to presumably oxidised rosin. Thus, 
      the differences seen in susceptibility in the regulatory tests may be reflected 
      in the human population. These results are discussed in terms of possible testing 
      and classification strategies for dealing with existing chemicals, with 
      particular reference to the new European Union legislation.
FAU - Botham, P A
AU  - Botham PA
AD  - Syngenta CTL, Alderley Park, Macclesfield, Cheshire SK10 4TF, UK.
FAU - Lees, D
AU  - Lees D
FAU - Illing, H P A
AU  - Illing HP
FAU - Malmfors, Torbjorn
AU  - Malmfors T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080604
PL  - Netherlands
TA  - Regul Toxicol Pharmacol
JT  - Regulatory toxicology and pharmacology : RTP
JID - 8214983
RN  - 0 (Allergens)
RN  - 0 (Resins, Plant)
RN  - 0 (Tars)
RN  - 88S87KL877 (rosin)
SB  - IM
MH  - Allergens/chemistry/toxicity
MH  - Animals
MH  - Guinea Pigs
MH  - Humans
MH  - Immunization/*methods
MH  - Mice
MH  - Models, Animal
MH  - Oxidation-Reduction
MH  - Patch Tests/*methods
MH  - Pinus
MH  - Resins, Plant/*chemistry/*toxicity
MH  - Skin/*drug effects/immunology
MH  - Tars/chemistry/toxicity
MH  - Toxicity Tests/*methods
EDAT- 2008/07/01 09:00
MHDA- 2009/02/28 09:00
CRDT- 2008/07/01 09:00
PHST- 2008/01/30 00:00 [received]
PHST- 2008/04/28 00:00 [revised]
PHST- 2008/05/13 00:00 [accepted]
PHST- 2008/07/01 09:00 [pubmed]
PHST- 2009/02/28 09:00 [medline]
PHST- 2008/07/01 09:00 [entrez]
AID - S0273-2300(08)00105-0 [pii]
AID - 10.1016/j.yrtph.2008.05.013 [doi]
PST - ppublish
SO  - Regul Toxicol Pharmacol. 2008 Dec;52(3):257-63. doi: 10.1016/j.yrtph.2008.05.013. 
      Epub 2008 Jun 4.