PMID- 18586400
OWN - NLM
STAT- MEDLINE
DCOM- 20081105
LR  - 20131121
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 441
IP  - 1
DP  - 2008 Aug 15
TI  - Frequency modulation of synchronized Ca(2+) spikes in cultured hippocampal 
      networks through mTOR.
PG  - 50-5
LID - 10.1016/j.neulet.2008.06.006 [doi]
AB  - The atypical serine/threonine protein kinase, a mammalian target of rapamycin 
      (mTOR), is believed to be essential to the regulation of cell growth and the 
      functions of the central nervous system. By using calcium imaging and 
      patch-clamping techniques to study the role of this signaling pathway in the 
      activity of cultured hippocampal neurons, we found that rapamycin significantly 
      reduces the spontaneous activities of network neurons as well as the efficacy of 
      synaptic transmission through insulin-mTOR signaling pathway. Our study sheds 
      light on understanding the role of mTOR signaling pathway in controlling the 
      information processing of network neurons.
FAU - Li, Ru-Xin
AU  - Li RX
AD  - Department of Biological Sciences and Biotechnology, National State Key 
      Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, 
      Beijing, China.
FAU - Yu, Xin-Zhu
AU  - Yu XZ
FAU - Fu, Min
AU  - Fu M
FAU - Zong, Min
AU  - Zong M
FAU - Liu, Ru-Lin
AU  - Liu RL
FAU - Xie, Zuo-Ping
AU  - Xie ZP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080607
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Enzyme Inhibitors)
RN  - SY7Q814VUP (Calcium)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Action Potentials/*drug effects/physiology
MH  - Animals
MH  - Calcium/*metabolism
MH  - Calcium Signaling/*drug effects/physiology
MH  - Cells, Cultured
MH  - Dose-Response Relationship, Drug
MH  - Dose-Response Relationship, Radiation
MH  - Electric Stimulation
MH  - Embryo, Mammalian
MH  - Enzyme Inhibitors/*pharmacology
MH  - Hippocampus/*cytology
MH  - Neurons/*drug effects/physiology
MH  - Patch-Clamp Techniques
MH  - Rats
MH  - Sirolimus/*pharmacology
MH  - Time Factors
EDAT- 2008/07/01 09:00
MHDA- 2008/11/06 09:00
CRDT- 2008/07/01 09:00
PHST- 2008/02/29 00:00 [received]
PHST- 2008/05/14 00:00 [revised]
PHST- 2008/06/03 00:00 [accepted]
PHST- 2008/07/01 09:00 [pubmed]
PHST- 2008/11/06 09:00 [medline]
PHST- 2008/07/01 09:00 [entrez]
AID - S0304-3940(08)00805-7 [pii]
AID - 10.1016/j.neulet.2008.06.006 [doi]
PST - ppublish
SO  - Neurosci Lett. 2008 Aug 15;441(1):50-5. doi: 10.1016/j.neulet.2008.06.006. Epub 
      2008 Jun 7.