PMID- 18587705
OWN - NLM
STAT- MEDLINE
DCOM- 20080820
LR  - 20211203
IS  - 1641-4640 (Print)
IS  - 1509-572X (Linking)
VI  - 46
IP  - 2
DP  - 2008
TI  - Implication of active Erk in the classic type of human medulloblastoma.
PG  - 117-22
AB  - Molecular pathways underlying medulloblastoma (MB), the most common malignant 
      brain tumour in children, are still under scrutiny. The mammalian target of the 
      rapamycin (mTOR) pathway is one of the kinases that was recently found to be 
      implicated in a number of human tumours. Also in the case of MB it is suspected 
      that mTOR dysregulation may play an important role in pathogenesis. Active mTOR 
      leads to translation of several proteins, some of which affect cellular 
      proliferation. On the other hand, Akt/PKB (protein kinase B) and Erk 
      (extracellular signal-regulated kinase, also called mitogen-activated protein 
      kinase, MAPK) are two protein kinases whose hyperactivity leads to a number of 
      downstream effects, including activation of mTOR. In our previous report we found 
      that indeed Akt and Erk are variably activated in human MBs. However, because MBs 
      are a highly heterogeneous group of tumours, we were unable to associate Akt or 
      Erk activation with all the cases of MB. In this paper we evaluated six cases of 
      MB, only of the classic subtype. We found that elements of the Erk pathway are 
      hyperactive in all six tumours. Thus, we postulate that in classic type of MB, 
      growth factor stimulation may lead to Erk upregulation and mTOR-dependent protein 
      translation, causing malignant growth.
FAU - Wlodarski, Pawel K
AU  - Wlodarski PK
AD  - Department of Histology and Embryology, Centre for Biostructure Research, Medical 
      University of Warsaw, Warsaw, Poland.
FAU - Boszczyk, Anna
AU  - Boszczyk A
FAU - Grajkowska, Wieslawa
AU  - Grajkowska W
FAU - Roszkowski, Marcin
AU  - Roszkowski M
FAU - Jozwiak, Jaroslaw
AU  - Jozwiak J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Folia Neuropathol
JT  - Folia neuropathologica
JID - 9437431
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
SB  - IM
MH  - Brain Neoplasms/*genetics/*pathology
MH  - Cells, Cultured
MH  - Humans
MH  - Medulloblastoma/*genetics/*pathology
MH  - Mitogen-Activated Protein Kinase 1/*genetics
MH  - Protein Kinases/*genetics
MH  - TOR Serine-Threonine Kinases
EDAT- 2008/07/01 09:00
MHDA- 2008/08/21 09:00
CRDT- 2008/07/01 09:00
PHST- 2008/07/01 09:00 [pubmed]
PHST- 2008/08/21 09:00 [medline]
PHST- 2008/07/01 09:00 [entrez]
AID - 10626 [pii]
PST - ppublish
SO  - Folia Neuropathol. 2008;46(2):117-22.