PMID- 18588558
OWN - NLM
STAT- MEDLINE
DCOM- 20080730
LR  - 20220310
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 63
IP  - 7
DP  - 2008 Jul
TI  - Reported food allergy to peanut, tree nuts and fruit: comparison of clinical 
      manifestations, prescription of medication and impact on daily life.
PG  - 910-6
LID - 10.1111/j.1398-9995.2008.01688.x [doi]
AB  - BACKGROUND: Peanut (PN), tree nuts (TN) and fruits are frequent causes of food 
      allergy (FA). Peanut and TN are believed to cause more severe reactions than 
      fruits. However, there are no studies comparing the severity of PN, TN and fruit 
      allergy within one patient group. METHODS: Four-hundred and eleven adult patients 
      referred to our tertiary allergy center with suspicion of FA completed a 
      standardized questionnaire. Patients with a typical history of immunoglobulin E 
      (IgE)-mediated allergy, e.g. oropharyngeal symptoms to PN, TN (hazelnut, walnut, 
      cashew nut) or fruit (apple, kiwi, peach, pear and cherry) were recruited 
      (218/411). The objective was to evaluate differences in clinical severity between 
      PN, TN and fruit allergy and how this was reflected by prescription of emergency 
      medication and impact on daily life. RESULTS: Eighty-two percent of the included 
      218 patients were sensitized to the respective foods. The percentages of severe 
      symptoms (i.e. respiratory or cardiovascular symptoms) in PN, TN and fruit 
      allergic patients were respectively 47%, 39% and 31% (respiratory) and 11%, 5.0% 
      and 3.4% (cardiovascular). Prescription and use of emergency medication 
      (epinephrine, antihistamines and steroids) did not differ among the three groups. 
      The majority of patients with a PN or TN allergy (72%) and fruit allergy (62%) 
      reported that FA influences their daily life considerably. CONCLUSIONS: Fruit 
      allergy causes less severe symptoms than TN and especially PN allergy. However, 
      this is not reflected in the prescription or use of emergency medication. This 
      may indicate that physicians are not fully acquainted with the guidelines for 
      prescription of emergency medication. A high impact on daily life was found both 
      in PN, TN and in fruit allergy.
FAU - Le, T M
AU  - Le TM
AD  - Department of Dermatology/Allergology, University Medical Center Utrecht, 
      Utrecht, the Netherlands.
FAU - Lindner, T M
AU  - Lindner TM
FAU - Pasmans, S G
AU  - Pasmans SG
FAU - Guikers, C L H
AU  - Guikers CL
FAU - van Hoffen, E
AU  - van Hoffen E
FAU - Bruijnzeel-Koomen, C A F M
AU  - Bruijnzeel-Koomen CA
FAU - Knulst, A C
AU  - Knulst AC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adult
MH  - Anaphylaxis/drug therapy/epidemiology
MH  - Cohort Studies
MH  - *Emergency Treatment
MH  - Epinephrine/therapeutic use
MH  - Europe
MH  - Female
MH  - Fruit/*adverse effects
MH  - Humans
MH  - Male
MH  - Nut Hypersensitivity/drug therapy/*epidemiology
MH  - Outcome Assessment, Health Care
MH  - Peanut Hypersensitivity/drug therapy/*epidemiology
MH  - Quality of Life
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
EDAT- 2008/07/01 09:00
MHDA- 2008/07/31 09:00
CRDT- 2008/07/01 09:00
PHST- 2008/07/01 09:00 [pubmed]
PHST- 2008/07/31 09:00 [medline]
PHST- 2008/07/01 09:00 [entrez]
AID - ALL1688 [pii]
AID - 10.1111/j.1398-9995.2008.01688.x [doi]
PST - ppublish
SO  - Allergy. 2008 Jul;63(7):910-6. doi: 10.1111/j.1398-9995.2008.01688.x.