PMID- 1858860
OWN - NLM
STAT- MEDLINE
DCOM- 19910827
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 261
IP  - 1 Pt 1
DP  - 1991 Jul
TI  - Carbohydrate supplementation attenuates IMP accumulation in human muscle during 
      prolonged exercise.
PG  - C71-6
AB  - The effect of carbohydrate (CHO) ingestion on metabolic responses to exercise has 
      been investigated. Subjects cycled at approximately 70% of maximal oxygen uptake 
      to fatigue [135 +/- 17 (+/- SE) min] on the first occasion (control, CON) and at 
      the same work load and duration on the second occasion but with addition of 
      ingestion of CHO during the exercise. Biopsies were taken from the quadriceps 
      femoris muscle before and after exercise. The sum of the hexose monophosphates 
      (HMP), as well as lactate and alanine, in muscle was higher after CHO exercise (P 
      less than or equal to 0.05, P less than or equal to 0.05, and P less than or 
      equal to 0.01, respectively). Acetylcarnitine increased during exercise but was 
      not significantly different between treatments after exercise (CON, 6.6 +/- 1.7; 
      CHO, 10.0 +/- 1.2 mmol/kg dry wt; P = NS). The sum of the tricarboxylic acid 
      cycle intermediates (TCAI; citrate + malate + fumarate) was increased during 
      exercise and was higher after CHO exercise (2.34 +/- 0.32 vs. 1.68 +/- 0.17 
      mmol/kg dry wt; P less than or equal to 0.05). IMP was less than 0.1 mmol/kg dry 
      wt at rest and increased to 0.77 +/- 0.26 (CON) and 0.29 +/- 0.11 mmol/kg dry wt 
      (CHO) (P less than or equal to 0.05) during exercise. It was recently found that 
      during prolonged exercise there is initially a rapid and large expansion of TCAI 
      and glycogenolytic intermediates in human muscle followed by a continuous decline 
      in TCAI and glycogenolytic intermediates [K. Sahlin, A. Katz, and S. Broberg. Am. 
      J. Physiol. 259 (Cell Physiol. 28): C834-C841, 1990].(ABSTRACT TRUNCATED AT 250 
      WORDS)
FAU - Spencer, M K
AU  - Spencer MK
AD  - Department of Kinesiology, University of Illinois, Urbana 61801.
FAU - Yan, Z
AU  - Yan Z
FAU - Katz, A
AU  - Katz A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Fatty Acids)
RN  - 0 (Insulin)
RN  - 0 (Phosphates)
RN  - 0 (Purine Nucleotides)
RN  - 0 (Tricarboxylic Acids)
RN  - 0U46U6E8UK (NAD)
RN  - 131-99-7 (Inosine Monophosphate)
RN  - 9005-79-2 (Glycogen)
RN  - S7UI8SM58A (Carnitine)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Carnitine/metabolism
MH  - Dietary Carbohydrates/*administration & dosage/metabolism
MH  - Fatty Acids/blood
MH  - Female
MH  - Glycogen/metabolism
MH  - Heart Rate
MH  - Humans
MH  - Inosine Monophosphate/*metabolism
MH  - Insulin/blood
MH  - Male
MH  - Middle Aged
MH  - Muscle Contraction
MH  - Muscles/*metabolism
MH  - NAD/metabolism
MH  - Oxidation-Reduction
MH  - Phosphates/metabolism
MH  - Physical Exertion/*physiology
MH  - Purine Nucleotides/metabolism
MH  - Respiration
MH  - Tricarboxylic Acids/metabolism
OID - NASA: 91314699
EDAT- 1991/07/01 00:00
MHDA- 1991/07/01 00:01
CRDT- 1991/07/01 00:00
PHST- 1991/07/01 00:00 [pubmed]
PHST- 1991/07/01 00:01 [medline]
PHST- 1991/07/01 00:00 [entrez]
AID - 10.1152/ajpcell.1991.261.1.C71 [doi]
PST - ppublish
SO  - Am J Physiol. 1991 Jul;261(1 Pt 1):C71-6. doi: 10.1152/ajpcell.1991.261.1.C71.