PMID- 18591141
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20191110
IS  - 1353-8020 (Print)
IS  - 1353-8020 (Linking)
VI  - 5
IP  - 4
DP  - 1999 Dec
TI  - Reactive oxygen species in NMDA receptor-mediated glutamate neurotoxicity.
PG  - 203-7
AB  - In search of endogenous protective substances that inhibit neurotoxic action of 
      glutamate and nitric oxide (NO), we found that brain-derived neurotrophic factor 
      (BDNF), acting on TrkB receptor tyrosine kinase, inhibited neurotoxicity induced 
      by glutamate and NO donors in cultured cortical neurons. In co-cultures of the 
      mesencephalon and striatum, projection of mesencephalic dopamine neurons to the 
      striatum attenuated N-methyl-d-aspartate (NMDA)-induced cytotoxicity in dopamine 
      neurons themselves. Growth factors such as neurotrophins, which the target cells 
      in the striatum would synthesize and secrete, may offer the protection of 
      dopamine neurons against glutamate neurotoxicity.
FAU - Akaike, A
AU  - Akaike A
AD  - Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto 
      University, Kyoto 606-8501, Japan.
FAU - Katsuki, H
AU  - Katsuki H
FAU - Kume, T
AU  - Kume T
FAU - Maeda, T
AU  - Maeda T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Parkinsonism Relat Disord
JT  - Parkinsonism & related disorders
JID - 9513583
EDAT- 2008/07/02 09:00
MHDA- 2008/07/02 09:01
CRDT- 2008/07/02 09:00
PHST- 2008/07/02 09:00 [pubmed]
PHST- 2008/07/02 09:01 [medline]
PHST- 2008/07/02 09:00 [entrez]
AID - S1353-8020(99)00038-3 [pii]
AID - 10.1016/s1353-8020(99)00038-3 [doi]
PST - ppublish
SO  - Parkinsonism Relat Disord. 1999 Dec;5(4):203-7. doi: 
      10.1016/s1353-8020(99)00038-3.