PMID- 18591156
OWN - NLM
STAT- MEDLINE
DCOM- 20080829
LR  - 20201209
IS  - 1121-760X (Print)
IS  - 1121-760X (Linking)
VI  - 52
IP  - 2
DP  - 2008 Apr-Jun
TI  - Effects of castration on the immunoreactivity to NGF, BDNF and their receptors in 
      the pelvic ganglia of the male rat.
PG  - 101-6
AB  - Nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) and are 
      members of the neurotrophin family, a family of neurotrophic factors that also 
      includes neurotrophin (NT) 3 and NT4/5. Neurotrophins have essential roles in the 
      survival, development and differentiation of neurons in the central and 
      peripheral nervous systems. Neurotrophins exert their effects by binding to 
      corresponding receptors which are formed by the tyrosine protein kinases TrkA, 
      TrkB and TrkC, and the low affinity neurotrophic receptor (p75NTR). In the 
      present study, using immunohistochemistry and quantitative analysis, we have 
      investigated immunoreactivity to BDNF, NGF, TrkB, p75NTR and TrkA in the pelvic 
      ganglia of normal and castrated rats. Neurons of the pelvic ganglia expressed 
      both these neurotrophins and their receptors. After castration the 
      immunoreactivity persisted. However, the number of BDNF- and p75NTR-IR cells 
      statistically significant decreased after castration. These results suggest that 
      castration modulates the expression of neurotrophins and their receptors in 
      pelvic autonomic neurons.
FAU - Squillacioti, Caterina
AU  - Squillacioti C
AD  - Department of Structures, Functions and Biological Technologies, University of 
      Naples Federico II, Via Veterinaria 1, 80137, Napoli, Italy. 
      caterina.squillacioti@unina.it
FAU - De Luca, A
AU  - De Luca A
FAU - Paino, G
AU  - Paino G
FAU - Mirabella, N
AU  - Mirabella N
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur J Histochem
JT  - European journal of histochemistry : EJH
JID - 9207930
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Growth Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 136958-07-1 (Ngfr protein, rat)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - EC 2.7.10.1 (Receptor, trkA)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Ganglia, Autonomic/*metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Nerve Growth Factor/*metabolism
MH  - Nerve Tissue Proteins
MH  - Orchiectomy
MH  - Pelvis/innervation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkA/*metabolism
MH  - Receptor, trkB/*metabolism
MH  - Receptors, Growth Factor
MH  - Receptors, Nerve Growth Factor/*metabolism
EDAT- 2008/07/02 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/07/02 09:00
PHST- 2008/07/02 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/07/02 09:00 [entrez]
AID - 10.4081/1194 [doi]
PST - ppublish
SO  - Eur J Histochem. 2008 Apr-Jun;52(2):101-6. doi: 10.4081/1194.