PMID- 18593277
OWN - NLM
STAT- MEDLINE
DCOM- 20080821
LR  - 20161124
IS  - 1549-1684 (Print)
IS  - 1549-1684 (Linking)
VI  - 11
IP  - 3
DP  - 2008 Jun
TI  - Caloric restriction retards the age-related decline in mitochondrial function of 
      brown adipose tissue.
PG  - 597-604
LID - 10.1089/rej.2007.0626 [doi]
AB  - Caloric restriction (CR) has been shown to prevent the age-associated loss of 
      mitochondrial function and biogenesis in several tissues such as liver, heart, 
      and skeletal muscle. However, little is known about the effects of CR on a tissue 
      in which the mitochondria have no adenosine triphosphate (ATP)-producing purpose 
      but show a high degree of uncoupling, namely brown adipose tissue (BAT). Hence, 
      the aim of the present study was to analyze the effect of long-term CR on BAT 
      mitochondrial function and biogenesis. BAT mitochondria obtained from 
      24-month-old male and female rats previously subjected to 40% CR for 12 months 
      were compared with mitochondria from old (24 months) and young (6 months) ad 
      libitum fed rats. Old restricted rats compared to old ad libitum fed ones showed 
      a reduction in BAT size with respect to fat content and adipocyte number. 
      Mitochondrial DNA content in BAT increased with age and even more so in 
      restricted rats, indicating a summative effect of age and CR on mitochondrial 
      proliferation. CR induced resistance to lose total and mitochondrial protein, COX 
      activity, and uncoupling capacity with advancing age, in relation with a lower 
      decrease of mitochondrial transcription factor A (TFAM). In summary, our results 
      demonstrate CR prevents the age-associated decline in mitochondrial function in 
      BAT, probably in relation with a lower impairment of mitochondrial biogenesis.
FAU - Valle, Adamo
AU  - Valle A
AD  - Grup de Metabolisme Energetic i Nutricio, Departament de Biologia Fonamental i 
      Ciencies de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Ciber 
      Fisiopatologia Obesidad y Nutricion (CB06/03) Instituto Salud Carlos III, Spain.
FAU - Guevara, Rocio
AU  - Guevara R
FAU - Garcia-Palmer, Francisco Jose
AU  - Garcia-Palmer FJ
FAU - Roca, Pilar
AU  - Roca P
FAU - Oliver, Jordi
AU  - Oliver J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Rejuvenation Res
JT  - Rejuvenation research
JID - 101213381
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Ion Channels)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (TFAM protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (Uncoupling Protein 1)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
MH  - Adenosine Triphosphate/biosynthesis
MH  - Adipose Tissue, Brown/*metabolism
MH  - Aging/*metabolism
MH  - Animals
MH  - Body Temperature Regulation
MH  - *Caloric Restriction
MH  - DNA-Binding Proteins/analysis/physiology
MH  - Female
MH  - Ion Channels/analysis/physiology
MH  - Male
MH  - Mitochondria/*physiology
MH  - Mitochondrial Proteins/analysis/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Transcription Factors/analysis/physiology
MH  - Uncoupling Protein 1
EDAT- 2008/07/03 09:00
MHDA- 2008/08/22 09:00
CRDT- 2008/07/03 09:00
PHST- 2008/07/03 09:00 [pubmed]
PHST- 2008/08/22 09:00 [medline]
PHST- 2008/07/03 09:00 [entrez]
AID - 10.1089/rej.2007.0626 [doi]
PST - ppublish
SO  - Rejuvenation Res. 2008 Jun;11(3):597-604. doi: 10.1089/rej.2007.0626.