PMID- 18593440
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20220317
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 60
IP  - 1
DP  - 2008 Jul
TI  - Studies on the compatibility of HLA-Class II alleles in patient couples with 
      severe pre-eclampsia using PCR-RFLP methods.
PG  - 75-84
LID - 10.1111/j.1600-0897.2008.00592.x [doi]
AB  - PROBLEM: In this study, we investigated whether or not significant compatibility 
      of human leukocyte antigen (HLA)-class II alleles exists between spouses with 
      severe pre-eclampsia (PE) (including gestational hypertension, GH). METHOD OF 
      STUDY: The HLA-class II genotypes were determined using a polymerase chain 
      reaction-restriction fragment length polymorphism method. The number of 
      incompatible alleles in 57 patient couples with severe PE (including GH) were 
      determined, and compared with that in 74 control couples. RESULTS: The number of 
      patient couples and control couples with each number of mismatched alleles of the 
      HLA-DR, -DQ, and -DP genotypes was as follows. The number of patient couples with 
      zero, one, two, three, and four-allele mismatches was 41 (72.9%), and with five 
      and six-allele mismatches was 16 (27.1%). On the other hand, the number of 
      control couples with zero, one, two, three, and four-allele mismatches was 38 
      (51.4%), and with five and six-allele mismatches was 36 (48.6%). Thus, the number 
      of patient couples with five and six-allele mismatches was significantly lower 
      compared with that in control couples. The same result was obtained as regards 
      the mismatched alleles of the HLA-DR, -DQ, and -DP phenotypes. CONCLUSION: These 
      findings suggest that significant compatibility of HLA-class II alleles between 
      spouses is implicated in the genesis of PE (including GH).
FAU - Ooki, Izumi
AU  - Ooki I
AD  - Department of Obstetrics and Gynecology, Niigata University School of Medicine, 
      Niigata, Japan.
FAU - Takakuwa, Koichi
AU  - Takakuwa K
FAU - Akashi, Mami
AU  - Akashi M
FAU - Nonaka, Taro
AU  - Nonaka T
FAU - Yokoo, Tomokazu
AU  - Yokoo T
FAU - Tanaka, Kenichi
AU  - Tanaka K
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Family Characteristics
MH  - Female
MH  - Genotype
MH  - *Histocompatibility
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Male
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Restriction Fragment Length
MH  - Pre-Eclampsia/genetics
MH  - Pregnancy
MH  - *Spouses
EDAT- 2008/07/03 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/07/03 09:00
PHST- 2008/07/03 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/07/03 09:00 [entrez]
AID - AJI592 [pii]
AID - 10.1111/j.1600-0897.2008.00592.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2008 Jul;60(1):75-84. doi: 10.1111/j.1600-0897.2008.00592.x.