PMID- 18593851
OWN - NLM
STAT- MEDLINE
DCOM- 20081006
LR  - 20141120
IS  - 0193-1849 (Print)
IS  - 0193-1849 (Linking)
VI  - 295
IP  - 3
DP  - 2008 Sep
TI  - Oxytocin alleviates the neuroendocrine and cytokine response to bacterial 
      endotoxin in healthy men.
PG  - E686-91
LID - 10.1152/ajpendo.90263.2008 [doi]
AB  - Oxytocin is a hormone and neurotransmitter found to have anti-inflammatory 
      functions in rodents. Here we used experimental bacterial endotoxinemia to 
      examine the role of exogenous oxytocin administration on innate immune responses 
      in humans. Ten healthy men received, in a randomized, placebo-controlled, 
      crossover design, placebo, oxytocin, LPS, and LPS + oxytocin. Oxytocin treatment 
      resulted in a transient or prolonged reduction of endotoxin-induced increases in 
      plasma ACTH, cortisol, procalcitonin, TNF-alpha, IL-1 receptor antagonist, IL-4, 
      IL-6, macrophage inflammatory protein-1alpha, macrophage inflammatory 
      protein-1beta, monocyte chemoattractant protein-1 (MCP-1), interferon-inducible 
      protein 10, and VEGF. In vitro, oxytocin had no impact on LPS effects in 
      releasing TNF-alpha, IL-6, and MCP-1 in monocytes and peripheral blood 
      mononuclear cells from healthy human donors. In summary, oxytocin decreases the 
      neuroendocrine and cytokine activation caused by bacterial endotoxin in men, 
      possibly due to the pharmacological modulation of the cholinergic 
      anti-inflammatory pathway. Oxytocin might be a candidate for the therapy of 
      inflammatory diseases and conditions associated with high cytokine and VEGF 
      levels.
FAU - Clodi, Martin
AU  - Clodi M
AD  - Dept. of Medicine III, Medical Univ. of Vienna, Waehringer Guertel 18-20, A-1090, 
      Vienna, Austria. martin.clodi@meduniwien.ac.at
FAU - Vila, Greisa
AU  - Vila G
FAU - Geyeregger, Rene
AU  - Geyeregger R
FAU - Riedl, Michaela
AU  - Riedl M
FAU - Stulnig, Thomas M
AU  - Stulnig TM
FAU - Struck, Joachim
AU  - Struck J
FAU - Luger, Thomas A
AU  - Luger TA
FAU - Luger, Anton
AU  - Luger A
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20080701
PL  - United States
TA  - Am J Physiol Endocrinol Metab
JT  - American journal of physiology. Endocrinology and metabolism
JID - 100901226
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Endotoxins)
RN  - 0 (Hormones)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 50-56-6 (Oxytocin)
SB  - IM
MH  - Adult
MH  - Body Temperature/drug effects
MH  - Cell Separation
MH  - Chemokines/biosynthesis
MH  - Cross-Over Studies
MH  - Cytokines/*biosynthesis
MH  - Double-Blind Method
MH  - Endotoxins/*antagonists & inhibitors/*toxicity
MH  - Fever/chemically induced/physiopathology
MH  - Hormones/blood
MH  - Humans
MH  - In Vitro Techniques
MH  - Lipopolysaccharides/antagonists & inhibitors/toxicity
MH  - Male
MH  - Monocytes/drug effects/metabolism
MH  - Neurosecretory Systems/*drug effects
MH  - Oxytocin/*pharmacology
MH  - Vascular Endothelial Growth Factor A/biosynthesis
EDAT- 2008/07/03 09:00
MHDA- 2008/10/07 09:00
CRDT- 2008/07/03 09:00
PHST- 2008/07/03 09:00 [pubmed]
PHST- 2008/10/07 09:00 [medline]
PHST- 2008/07/03 09:00 [entrez]
AID - 90263.2008 [pii]
AID - 10.1152/ajpendo.90263.2008 [doi]
PST - ppublish
SO  - Am J Physiol Endocrinol Metab. 2008 Sep;295(3):E686-91. doi: 
      10.1152/ajpendo.90263.2008. Epub 2008 Jul 1.