PMID- 18594186
OWN - NLM
STAT- MEDLINE
DCOM- 20080916
LR  - 20191110
IS  - 1594-0667 (Print)
IS  - 1594-0667 (Linking)
VI  - 20
IP  - 3
DP  - 2008 Jun
TI  - Free testosterone levels and implications on clinical outcomes in elderly men.
PG  - 201-6
AB  - BACKGROUND AND AIMS: Aging is accompanied by a progressive decline in serum 
      testosterone. Evidence concerning the clinical manifestations of low serum 
      testosterone levels is contradictory. We aimed to examine the age-related decline 
      in testosterone and the possible clinical outcomes, including erectile 
      dysfunction, prostatism, cognitive function, daily life activities, depression, 
      and osteoporosis. METHODS: One hundred and twenty men underwent comprehensive 
      geriatric assessment. Testosterone and free testosterone levels were measured, 
      geriatric assessment scales, International Index of Erectile Function (IIEF) and 
      International Prostate Symptom Scale (IPSS) were performed, and bone mineral 
      densities were determined. RESULTS: The mean age of the 120 men was 73.8+/-5.90. 
      A significant decrease in testosterone and free testosterone levels with 
      increasing age was determined (p=0.021). It was also found that erectile 
      dysfunction, as determined by IIEF (r=0.66, p<0.001), and symptoms of prostatism 
      determined by IPSS (r=-0.23, p=0.016), were significantly associated with low 
      free testosterone levels. Laboratory parameters, obesity, osteoporosis, cognitive 
      function, daily life activities, and cardiovascular diseases were not 
      significantly different between groups with low and normal free testosterone 
      levels. CONCLUSION: Age-related decrease in free testosterone may lead to 
      erectile dysfunction and symptoms of prostatism in elderly men.
FAU - Yavuz, Burcu Balam
AU  - Yavuz BB
AD  - Division of Geriatric Medicine, Department of Internal Medicine, Hacettepe 
      University, 06100 Sihhiye, Ankara, Turkey. bbdogu@yahoo.com
FAU - Ozkayar, Nihal
AU  - Ozkayar N
FAU - Halil, Meltem
AU  - Halil M
FAU - Cankurtaran, Mustafa
AU  - Cankurtaran M
FAU - Ulger, Zekeriya
AU  - Ulger Z
FAU - Tezcan, Engin
AU  - Tezcan E
FAU - Gurlek, Alper
AU  - Gurlek A
FAU - Ariogul, Servet
AU  - Ariogul S
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Aging Clin Exp Res
JT  - Aging clinical and experimental research
JID - 101132995
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Aged
MH  - Erectile Dysfunction/blood
MH  - *Geriatrics
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - Sexual Behavior
MH  - Testosterone/*blood
EDAT- 2008/07/03 09:00
MHDA- 2008/09/17 09:00
CRDT- 2008/07/03 09:00
PHST- 2008/07/03 09:00 [pubmed]
PHST- 2008/09/17 09:00 [medline]
PHST- 2008/07/03 09:00 [entrez]
AID - 4658 [pii]
AID - 10.1007/BF03324771 [doi]
PST - ppublish
SO  - Aging Clin Exp Res. 2008 Jun;20(3):201-6. doi: 10.1007/BF03324771.