PMID- 18594780
OWN - NLM
STAT- MEDLINE
DCOM- 20090109
LR  - 20211020
IS  - 0925-5710 (Print)
IS  - 0925-5710 (Linking)
VI  - 88
IP  - 2
DP  - 2008 Sep
TI  - Evolutional change of karyotype with t(8;9)(p22;p24) and HLA-DR immunophenotype 
      in relapsed acute myeloid leukemia.
PG  - 197-201
LID - 10.1007/s12185-008-0113-4 [doi]
AB  - The rare recurrent translocation of (8;9)(p22;p24) with PCM1-JAK2 fusion was 
      recently characterized in diverse hematological malignancies. Most of them are 
      atypical chronic myeloid leukemia (CML) or other myeloproliferative disorders 
      (MPD), and are predominantly in the male. We report a female patient with acute 
      myeloid leukemia (AML) initially presenting with normal karyotype and negative 
      HLA-DR expression who achieved complete remission after standard chemotherapy. 
      The disease relapsed 7 months later with cytogenetic change of t(8;9)(p22;p24). 
      Flow cytometry analysis showed evolutional change of immunophenotype from 
      negative to positive HLA-DR expression and fluorescence in situ hybridization 
      (FISH) analysis demonstrated a PCM1-JAK2 fusion gene. We speculate that the 
      cytogenetic change of t(8;9)(p22;p24) may induce HLA-DR immunophenotypic switch 
      and a coordination of the two evolutional changes may play a role in leukemic 
      cell progression.
FAU - Huang, Kuan-Po
AU  - Huang KP
AD  - Division of Oncology and Hematology, Buddhist Tzu Chi General Hospital, 707, 
      Sec.3, Chung-Yang Rd., Hualien, Taiwan, ROC.
FAU - Chase, Andrew J
AU  - Chase AJ
AD  - Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, UK.
FAU - Cross, Nicholas C P
AU  - Cross NCP
AD  - Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, UK.
FAU - Reiter, Andrea
AU  - Reiter A
AD  - III. Medizinische Klinik, Medizinische Fakultat Mannheim der Universitat 
      Heidelberg, Mannheim, Germany.
FAU - Li, Tzu-Ying
AU  - Li TY
AD  - Cytogenetics Laboratory, Center for Medical Genetics, Buddhist Tzu Chi General 
      Hospital and Tzu Chi University, Hualien, Taiwan, ROC.
FAU - Wang, Tso-Fu
AU  - Wang TF
AD  - Division of Oncology and Hematology, Buddhist Tzu Chi General Hospital, 707, 
      Sec.3, Chung-Yang Rd., Hualien, Taiwan, ROC.
FAU - Chu, Sung-Chao
AU  - Chu SC
AD  - Division of Oncology and Hematology, Buddhist Tzu Chi General Hospital, 707, 
      Sec.3, Chung-Yang Rd., Hualien, Taiwan, ROC.
FAU - Lu, Xuan-Yin
AU  - Lu XY
AD  - Division of Oncology and Hematology, Buddhist Tzu Chi General Hospital, 707, 
      Sec.3, Chung-Yang Rd., Hualien, Taiwan, ROC.
FAU - Li, Chi-Cheng
AU  - Li CC
AD  - Division of Oncology and Hematology, Buddhist Tzu Chi General Hospital, 707, 
      Sec.3, Chung-Yang Rd., Hualien, Taiwan, ROC.
FAU - Kao, Ruey-Ho
AU  - Kao RH
AD  - Division of Oncology and Hematology, Buddhist Tzu Chi General Hospital, 707, 
      Sec.3, Chung-Yang Rd., Hualien, Taiwan, ROC. rueyhokao@tzuchi.org.tw.
AD  - Department of Oncology, Buddhist Tzu Chi University, Hualien, Taiwan, ROC. 
      rueyhokao@tzuchi.org.tw.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20080702
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (Autoantigens)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (PCM1 protein, human)
RN  - EC 2.7.10.2 (JAK2 protein, human)
RN  - EC 2.7.10.2 (Janus Kinase 2)
SB  - IM
MH  - Autoantigens/*genetics
MH  - Cell Cycle Proteins/*genetics
MH  - Chromosome Aberrations
MH  - Chromosomes, Human, Pair 8
MH  - Chromosomes, Human, Pair 9
MH  - Fatal Outcome
MH  - Female
MH  - Flow Cytometry
MH  - Gene Expression Regulation, Leukemic
MH  - HLA-DR Antigens/*genetics
MH  - Humans
MH  - Immunophenotyping
MH  - Janus Kinase 2/*genetics
MH  - Leukemia, Myeloid, Acute/*genetics/pathology
MH  - Middle Aged
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Recurrence
MH  - *Translocation, Genetic
EDAT- 2008/07/03 09:00
MHDA- 2009/01/10 09:00
CRDT- 2008/07/03 09:00
PHST- 2008/01/21 00:00 [received]
PHST- 2008/05/27 00:00 [accepted]
PHST- 2008/05/01 00:00 [revised]
PHST- 2008/07/03 09:00 [pubmed]
PHST- 2009/01/10 09:00 [medline]
PHST- 2008/07/03 09:00 [entrez]
AID - 10.1007/s12185-008-0113-4 [pii]
AID - 10.1007/s12185-008-0113-4 [doi]
PST - ppublish
SO  - Int J Hematol. 2008 Sep;88(2):197-201. doi: 10.1007/s12185-008-0113-4. Epub 2008 
      Jul 2.