PMID- 18595739
OWN - NLM
STAT- MEDLINE
DCOM- 20081208
LR  - 20161124
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 42
IP  - 2
DP  - 2008 Aug 15
TI  - Kinetic analyses of [123I]IBZM SPECT for quantification of striatal dopamine D2 
      receptor binding: a critical evaluation of the single-scan approach.
PG  - 548-58
LID - 10.1016/j.neuroimage.2008.05.023 [doi]
AB  - BACKGROUND: Dopamine-D2 receptor imaging with single-photon emission computed 
      tomography (SPECT) and [(123)I]IBZM is of great interest for basic and applied 
      neurosciences. However, the use of kinetic analyses for quantification of dynamic 
      [(123)I]IBZM SPECT and the validity of the commonly employed single-scan 
      pseudo-equilibrium analysis (PsEA) have not been appropriately investigated. The 
      present study addresses these shortcomings. METHODS: Ten movement disorder 
      patients underwent dynamic SPECT (142 min) after single-bolus [(123)I]IBZM 
      injection. Kinetic analyses comprise: simplified reference tissue model (SRTM), 
      multi-linear reference tissue model (MRTM), their two-parameter versions 
      (SRTM2/MRTM2) and non-invasive graphical analysis (NIGA). Simplified single-scan 
      analyses were performed at peak time of specific binding (peak-equilibrium 
      analysis, PEA) and during pseudo-equilibrium (PsEA). RESULTS: SRTM and MRTM are 
      compromised by the high noise level of dynamic SPECT. SRTM2 and MRTM2 yielded 
      reliable binding potential estimates that agreed excellently (mean 
      difference=-0.1+/-1.0%, R(2)>0.99). Concordance between SRTM/MRTM and SRTM2/MRTM2 
      was high in cases in which SRTM/MRTM provided reliable results (SRTM2 or MRTM2 
      vs. SRTM: 3.7+/-5.0%, R(2)=0.88). NIGA was affected by a negative bias 
      (-9.1+/-6.3%, R(2)=0.75; MRTM2 as reference) or high variability (-1.2+/-7.4%, 
      R(2)=0.71) for analyses without and with inclusion of the k(2)'-term, 
      respectively. PsEA showed a positive bias and low correlation in comparison with 
      SRTM2/MRTM2 (7.6+/-10.8%, R(2)=0.59), which was considerably improved for PEA 
      (-2.7+/-7.6%, R(2)=0.72). MRTM2 provided parametric images with minimal bias 
      suited for voxel-wise statistical analyses. CONCLUSIONS: MRTM2 and SRTM2 can be 
      reliably applied to dynamic [(123)I]IBZM SPECT. PEA is a suitable method for 
      clinical routine, while our results discourage the use of PsEA (current clinical 
      standard).
FAU - Meyer, Philipp T
AU  - Meyer PT
AD  - Department of Nuclear Medicine, University Hospital Aachen, Aachen, Germany. 
      pmeyer@ukaachen.de
FAU - Sattler, Bernhard
AU  - Sattler B
FAU - Winz, Oliver H
AU  - Winz OH
FAU - Fundke, Rico
AU  - Fundke R
FAU - Oehlwein, Christian
AU  - Oehlwein C
FAU - Kendziorra, Kai
AU  - Kendziorra K
FAU - Hesse, Swen
AU  - Hesse S
FAU - Schaefer, Wolfgang M
AU  - Schaefer WM
FAU - Sabri, Osama
AU  - Sabri O
LA  - eng
PT  - Journal Article
DEP - 20080523
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
RN  - 0 (Benzamides)
RN  - 0 (Pyrrolidines)
RN  - 0 (Radiopharmaceuticals)
RN  - 0 (Receptors, Dopamine D2)
RN  - 84226-06-2 
      (3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Benzamides/*pharmacokinetics
MH  - Corpus Striatum/diagnostic imaging/*metabolism
MH  - Female
MH  - Humans
MH  - Kinetics
MH  - Male
MH  - Metabolic Clearance Rate
MH  - Middle Aged
MH  - Movement Disorders/diagnostic imaging/*metabolism
MH  - Protein Binding
MH  - Pyrrolidines/*pharmacokinetics
MH  - Radiopharmaceuticals/pharmacokinetics
MH  - Receptors, Dopamine D2/*metabolism
MH  - Tomography, Emission-Computed, Single-Photon/*methods
EDAT- 2008/07/04 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/07/04 09:00
PHST- 2008/02/22 00:00 [received]
PHST- 2008/05/06 00:00 [revised]
PHST- 2008/05/15 00:00 [accepted]
PHST- 2008/07/04 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/07/04 09:00 [entrez]
AID - S1053-8119(08)00665-4 [pii]
AID - 10.1016/j.neuroimage.2008.05.023 [doi]
PST - ppublish
SO  - Neuroimage. 2008 Aug 15;42(2):548-58. doi: 10.1016/j.neuroimage.2008.05.023. Epub 
      2008 May 23.