PMID- 18597603
OWN - NLM
STAT- MEDLINE
DCOM- 20081009
LR  - 20111117
IS  - 0022-3492 (Print)
IS  - 0022-3492 (Linking)
VI  - 79
IP  - 7
DP  - 2008 Jul
TI  - Effect of periodontitis on insulin resistance and the onset of type 2 diabetes 
      mellitus in Zucker diabetic fatty rats.
PG  - 1208-16
LID - 10.1902/jop.2008.070605 [doi]
AB  - BACKGROUND: Studies indicate that an association exists between periodontitis and 
      type 2 diabetes mellitus (T2DM) and/or obesity, with chronic inflammation 
      hypothesized as the common denominator. The purpose of this study was to 
      determine the causal effect of periodontitis and the concomitant impact of diet 
      on the onset of insulin resistance (IR) and T2DM using a rat model system that 
      simulates human obesity and T2DM. METHODS: Twenty-eight, 5-week-old female Zucker 
      diabetic fatty (ZDF, fa/fa) rats were divided into four groups of seven animals: 
      high-fat fed-periodontitis (HF/P), high-fat fed-no periodontitis (HF/C), low-fat 
      fed-periodontitis (LF/P), and low-fat fed-no periodontitis (LF/C). Periodontitis 
      was induced by ligature placement. Fasting plasma insulin and glucose levels were 
      measured, and glucose tolerance tests were performed to assess glucose 
      homeostasis, IR, and the onset of T2DM. The level of tumor necrosis factor-alpha 
      (TNF-alpha), leptin, triglycerides, and free fatty acids were determined in week 
      13 at sacrifice. RESULTS: HF/P rats developed more severe IR compared to HF/C 
      rats (P <0.01) and LF/P or LF/C rats (P <0.001) as measured by fasting insulin 
      levels and homeostasis model assessment analysis. The onset of severe IR occurred 
      approximately 3 weeks earlier in HF/P rats compared to HF/C rats. HF/P rats 
      developed impaired (110 to 125 mg/dl) and frank fasting hyperglycemia (>125 
      mg/dl) 2 weeks earlier than HF/C rats. There was no difference in the severity 
      and onset of IR and T2DM between LF/P and LF/C rats. The level of TNF-alpha was 
      significantly higher in HF/P rats compared to HF/C rats (P <0.01). CONCLUSION: 
      Periodontitis accelerated the onset of severe IR and impaired glucose homeostasis 
      in high-fat fed ZDF rats.
FAU - Watanabe, Keiko
AU  - Watanabe K
AD  - Department of Periodontics, College of Dentistry, University of Illinois at 
      Chicago, Chicago, IL 60612-5176, USA. keiko@uic.edu
FAU - Petro, Benjamin J
AU  - Petro BJ
FAU - Shlimon, Alan E
AU  - Shlimon AE
FAU - Unterman, Terry G
AU  - Unterman TG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - 0 (Leptin)
RN  - 0 (Triglycerides)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Alveolar Bone Loss/etiology
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Type 2/*etiology
MH  - Diet, Fat-Restricted
MH  - Dietary Fats/administration & dosage
MH  - Disease Models, Animal
MH  - Fasting/blood
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Glucose Tolerance Test
MH  - Homeostasis/physiology
MH  - Hyperglycemia/etiology
MH  - Insulin/blood
MH  - Insulin Resistance/*physiology
MH  - Leptin/blood
MH  - Periodontitis/*complications/physiopathology
MH  - Rats
MH  - Rats, Zucker
MH  - Time Factors
MH  - Triglycerides/blood
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 2008/07/04 09:00
MHDA- 2008/10/10 09:00
CRDT- 2008/07/04 09:00
PHST- 2008/07/04 09:00 [pubmed]
PHST- 2008/10/10 09:00 [medline]
PHST- 2008/07/04 09:00 [entrez]
AID - 10.1902/jop.2008.070605 [doi]
PST - ppublish
SO  - J Periodontol. 2008 Jul;79(7):1208-16. doi: 10.1902/jop.2008.070605.