PMID- 18598323
OWN - NLM
STAT- MEDLINE
DCOM- 20081016
LR  - 20151119
IS  - 0886-0440 (Print)
IS  - 0886-0440 (Linking)
VI  - 23
IP  - 4
DP  - 2008 Jul-Aug
TI  - Plasma nitrate/nitrite (NOx) is not a useful biomarker to predict inherent 
      cardiopulmonary bypass inflammatory response.
PG  - 336-8
LID - 10.1111/j.1540-8191.2008.00649.x [doi]
AB  - BACKGROUND AND AIM: There were strong evidences that nitric oxide has capital 
      importance in the progressive vasodilatation associated with varied circulatory 
      shock forms, including systemic inflammatory response syndrome (SIRS), in 
      patients undergoing cardiac surgeries for cardiopulmonary bypass (CPB). If CPB 
      procedures, per se, are the inciting stimulus for inflammation, plasma 
      nitrate/nitrite (NOx) excretion would be expected to be higher in these patients 
      rather than in patients operated without CPB. In consequence, we hypothesized 
      that increased levels of NOx would be predictive for vasoplegic syndrome. 
      METHODS: Thirty patients were assigned to three groups: Group 1--coronary artery 
      bypass graft (CABG) roller pump CPB; Group 2--CABG centrifugal vortex pump CPB; 
      and Group 3--heart valve surgery roller pump CPB. Sampling of venous blood for 
      chemiluminescence plasma NOx dosage was achieved at the following time points: 
      (1) before anesthesia induction; (2) after anesthesia induction; (3) before 
      heparin infusion; (4) after heparin infusion; (5) CPB-30 minutes; (6) CPB-60 
      minutes; (7) before protamine infusion; (8) after protamine infusion; and (9) on 
      return to the recovery area. RESULTS: There were no intergroup differences 
      regarding age and anesthetic regimen, and the number of arteries grafted was not 
      different between the CABG groups. There were no NOx statistic differences, 
      neither among the three groups of patients or among the surgery time. In 
      addition, there was no correlation among NOx, lactate, and hemoglobin. 
      CONCLUSIONS: Considering the inflammatory process intrinsic to CPB, this study 
      reinforces the idea that plasma NOx is not useful as a biomarker of inflammatory 
      response onset, which may or may not lead to SIRS and/or vasoplegic syndrome.
FAU - Viaro, Fernanda
AU  - Viaro F
AD  - Division of Thoracic and Cardiovascular Surgery, Department of Surgery and 
      Anatomy, Ribeirao Preto Faculty of Medicine,University of Sao Paulo, Ribeirao 
      Preto, Sao Paulo, Brazil.
FAU - Baldo, Caroline Floreoto
AU  - Baldo CF
FAU - Capellini, Verena Kise
AU  - Capellini VK
FAU - Celotto, Andrea Carla
AU  - Celotto AC
FAU - Bassetto, Solange
AU  - Bassetto S
FAU - Rodrigues, Alfredo Jose
AU  - Rodrigues AJ
FAU - Evora, Paulo Roberto Barbosa
AU  - Evora PR
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Card Surg
JT  - Journal of cardiac surgery
JID - 8908809
RN  - 0 (Anticoagulants)
RN  - 0 (Biomarkers)
RN  - 0 (Hemoglobins)
RN  - 0 (Heparin Antagonists)
RN  - 0 (Nitrates)
RN  - 0 (Nitrites)
RN  - 0 (Protamines)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 9005-49-6 (Heparin)
SB  - IM
CIN - J Card Surg. 2009 May-Jun;24(3):357. doi: 10.1111/j.1540-8191.2009.00866.x. PMID: 
      19438801
MH  - Anesthesia, Inhalation
MH  - Anticoagulants/administration & dosage
MH  - Biomarkers/blood
MH  - Cardiopulmonary Bypass/*adverse effects/instrumentation
MH  - Coronary Artery Bypass
MH  - Heart Valves/surgery
MH  - Hemoglobins/analysis
MH  - Heparin/administration & dosage
MH  - Heparin Antagonists/administration & dosage
MH  - Humans
MH  - Lactic Acid/blood
MH  - Luminescent Measurements
MH  - Nitrates/*blood
MH  - Nitrites/*blood
MH  - Protamines/administration & dosage
MH  - Systemic Inflammatory Response Syndrome/*diagnosis/etiology
EDAT- 2008/07/05 09:00
MHDA- 2008/10/17 09:00
CRDT- 2008/07/05 09:00
PHST- 2008/07/05 09:00 [pubmed]
PHST- 2008/10/17 09:00 [medline]
PHST- 2008/07/05 09:00 [entrez]
AID - JCS649 [pii]
AID - 10.1111/j.1540-8191.2008.00649.x [doi]
PST - ppublish
SO  - J Card Surg. 2008 Jul-Aug;23(4):336-8. doi: 10.1111/j.1540-8191.2008.00649.x.