PMID- 18599090
OWN - NLM
STAT- MEDLINE
DCOM- 20080925
LR  - 20161124
IS  - 0025-326X (Print)
IS  - 0025-326X (Linking)
VI  - 56
IP  - 8
DP  - 2008 Aug
TI  - Multixenobiotic resistance, acetyl-choline esterase activity and total oxyradical 
      scavenging capacity of the Arctic spider crab, Hyasaraneus, following exposure to 
      bisphenol A, tetra bromo diphenyl ether and diallyl phthalate.
PG  - 1410-5
LID - 10.1016/j.marpolbul.2008.05.005 [doi]
AB  - The Arctic has become a sink for persistent organic pollutants (POPs) originating 
      from lower latitudes, and relatively high levels have been found in different 
      biota. Recent studies have identified detrimental effects on wildlife including 
      endocrine disruption, impairment of enzyme activity, and reduced immune function. 
      The Arctic spider crab, Hyas araneus, shown interesting potential for its use as 
      sentinel organism in polar ecosystems. This study investigated the effect of 
      2,2',4,4'-tetra bromo diphenyl ether (BPDE), bisphenol A (BPA), and diallyl 
      phthalte (DPA) on H. araneus in a three weeks exposure study. Expression of 
      multixenibiotic resistance (MXR) proteins has been studied using the C219 
      monoclonal antibody which allows identifying an immunoreactive protein of 40 kDa 
      in the digestive gland while no such protein could be observed in the gills. 
      Expression of this protein was increased by exposure to DPA (+75%; p<0.05, n=10). 
      All compounds significantly affected muscle acetylcholine esterase (AChE) 
      activity (p<0.05, n=10) with 50 microg/L DPA having the strongest effect by 
      lowering the value to 37% of control. The total oxyradical scavenging capacity 
      measured in the digestive gland toward peroxyl, hydroxyl and peroxynitrite was 
      also significantly reduced indicating a decreased resistance to oxidative stress 
      generated by DPA (p<0.05, n=5). These results thus suggest the potential 
      detrimental effects of DPA even at concentration as low as 50 microg/L on H. 
      araneus.
FAU - Minier, Christophe
AU  - Minier C
AD  - LEMA, EA 3222, Universite du Havre, 25, rue Philippe Lebon, BP540, F-76058 Le 
      Havre, France. minier@univ-lehavre.fr
FAU - Forget-Leray, Joelle
AU  - Forget-Leray J
FAU - Bjornstad, Anne
AU  - Bjornstad A
FAU - Camus, Lionel
AU  - Camus L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080702
PL  - England
TA  - Mar Pollut Bull
JT  - Marine pollution bulletin
JID - 0260231
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Brominated)
RN  - 0 (Phenols)
RN  - 0 (Phenyl Ethers)
RN  - 0 (Phthalic Acids)
RN  - 0 (Polybrominated Biphenyls)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Water Pollutants)
RN  - 0 (Xenobiotics)
RN  - 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
RN  - F79L0UL6ST (diallyl phthalate)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Acetylcholinesterase/*metabolism
MH  - Animals
MH  - Arctic Regions
MH  - Benzhydryl Compounds
MH  - Brachyura/*drug effects/*enzymology
MH  - Digestive System/drug effects
MH  - *Drug Resistance, Multiple
MH  - Gene Expression Regulation/drug effects
MH  - Halogenated Diphenyl Ethers
MH  - Hydrocarbons, Brominated/pharmacology/toxicity
MH  - Muscles/drug effects/enzymology
MH  - Phenols/pharmacology/toxicity
MH  - Phenyl Ethers/pharmacology/toxicity
MH  - Phthalic Acids/toxicity
MH  - Polybrominated Biphenyls
MH  - Reactive Oxygen Species/*metabolism
MH  - Water Pollutants/pharmacology/*toxicity
MH  - Xenobiotics/*pharmacology/toxicity
EDAT- 2008/07/05 09:00
MHDA- 2008/09/26 09:00
CRDT- 2008/07/05 09:00
PHST- 2007/12/17 00:00 [received]
PHST- 2008/04/30 00:00 [revised]
PHST- 2008/05/12 00:00 [accepted]
PHST- 2008/07/05 09:00 [pubmed]
PHST- 2008/09/26 09:00 [medline]
PHST- 2008/07/05 09:00 [entrez]
AID - S0025-326X(08)00268-3 [pii]
AID - 10.1016/j.marpolbul.2008.05.005 [doi]
PST - ppublish
SO  - Mar Pollut Bull. 2008 Aug;56(8):1410-5. doi: 10.1016/j.marpolbul.2008.05.005. 
      Epub 2008 Jul 2.