PMID- 18599372
OWN - NLM
STAT- MEDLINE
DCOM- 20081216
LR  - 20211203
IS  - 1878-7568 (Electronic)
IS  - 1742-7061 (Linking)
VI  - 4
IP  - 6
DP  - 2008 Nov
TI  - Nucleation and growth of apatite on NaOH-treated PEEK, HDPE and UHMWPE for 
      artificial cornea materials.
PG  - 1827-36
LID - 10.1016/j.actbio.2008.05.004 [doi]
AB  - The skirt of an artificial cornea must integrate the implant to the host sclera, 
      a major failure of present devices. Thus, it is highly desirable to encourage the 
      metabolic activity of the cornea by using more bioactive, flexible skirt 
      materials. Here we describe attempts to increase the bioactivity of polyether 
      ether ketone (PEEK), high-density polyethylene (HDPE) and ultra-high molecular 
      weight polyethylene (UHMWPE) films. The effectiveness of different strength NaOH 
      pre-treatments to initiate apatite deposition on PEEK, HDPE and UHMWPE is 
      investigated. We find that exposure of PEEK, HDPE and UHMWPE films to NaOH 
      solutions induces the formation of potential nuclei for apatite (calcium 
      phosphate), from which the growth of an apatite coating is stimulated when 
      subsequently immersing the polymer films in 1.5 strength Simulated Body Fluid 
      (SBF). As immersion time in SBF increases, further nucleation and growth produces 
      a thicker and more compact apatite coating that can be expected to be highly 
      bioactive. Interestingly, the apatite growth is found to also be dependent on 
      both the concentration of NaOH solution and the structure of the polymer surface.
FAU - Pino, M
AU  - Pino M
AD  - Department of Mechanical Engineering, University of Glasgow, Glasgow G12 8QQ, UK. 
      m.pino@eng.gla.ac.uk
FAU - Stingelin, N
AU  - Stingelin N
FAU - Tanner, K E
AU  - Tanner KE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080523
PL  - England
TA  - Acta Biomater
JT  - Acta biomaterialia
JID - 101233144
RN  - 0 (Apatites)
RN  - 0 (Benzophenones)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Calcium Phosphates)
RN  - 0 (Ions)
RN  - 0 (Ketones)
RN  - 0 (Polyethylenes)
RN  - 0 (Polymers)
RN  - 0 (ultra-high molecular weight polyethylene)
RN  - 31694-16-3 (polyetheretherketone)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 55X04QC32I (Sodium Hydroxide)
RN  - 9002-88-4 (Polyethylene)
RN  - 97Z1WI3NDX (calcium phosphate)
SB  - IM
MH  - Apatites/chemistry
MH  - Benzophenones
MH  - Biocompatible Materials/*chemistry
MH  - Body Fluids/metabolism
MH  - Calcium Phosphates/chemistry
MH  - Cell Proliferation
MH  - Cornea/*metabolism
MH  - Ions
MH  - Ketones/*chemistry
MH  - Microscopy, Electron, Scanning
MH  - Polyethylene/*chemistry
MH  - Polyethylene Glycols/*chemistry
MH  - Polyethylenes/*chemistry
MH  - Polymers/chemistry
MH  - Sodium Hydroxide/*chemistry
MH  - Spectroscopy, Fourier Transform Infrared/methods
MH  - Spectrum Analysis, Raman/methods
EDAT- 2008/07/05 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/07/05 09:00
PHST- 2008/01/22 00:00 [received]
PHST- 2008/04/07 00:00 [revised]
PHST- 2008/05/09 00:00 [accepted]
PHST- 2008/07/05 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/07/05 09:00 [entrez]
AID - S1742-7061(08)00128-1 [pii]
AID - 10.1016/j.actbio.2008.05.004 [doi]
PST - ppublish
SO  - Acta Biomater. 2008 Nov;4(6):1827-36. doi: 10.1016/j.actbio.2008.05.004. Epub 
      2008 May 23.