PMID- 18600033 OWN - NLM STAT- MEDLINE DCOM- 20080915 LR - 20220318 IS - 1423-0224 (Electronic) IS - 0302-282X (Linking) VI - 57 IP - 3 DP - 2008 TI - Association of polymorphism (Val66Met) of brain-derived neurotrophic factor with suicide attempts in depressed patients. PG - 139-45 LID - 10.1159/000142361 [doi] AB - INTRODUCTION: Recent post-mortem studies of suicide victims have implicated brain-derived neurotrophic factor (BDNF) in suicide. Therefore, it was decided to examine the possible role of a gene in the regulation of BDNF activity in relation to suicidal behaviour among depressed patients. METHOD: A series of 170 depressed patients were evaluated for their history of suicide attempts and genotyped for the BDNF Val66Met polymorphism (SNP ID: rs6265). Depressed patients who had (n = 97) or had not (n = 73) attempted suicide were compared. RESULTS: Depressed patients who carried the BDNF Val66Met polymorphism variant (GA + AA) appeared to show a significantly increased risk of suicidal behaviour. The risk of a suicide attempt was also significantly higher among those reporting higher levels of childhood emotional, physical and sexual abuse. Secondary analyses suggested that depression severity was a significant risk factor only in the wild-type BDNF genotype, and that the risk of suicide attempts was more predictable within the wild-type group. CONCLUSION: These preliminary data suggest that BDNF may play a role in the suicidal behaviour of depressed patients. CI - Copyright 2008 S. Karger AG, Basel. FAU - Sarchiapone, Marco AU - Sarchiapone M AD - Department of Health Sciences, University of Molise, Campobasso, Italy. marco.sarchiapone@gmail.com FAU - Carli, Vladimir AU - Carli V FAU - Roy, Alec AU - Roy A FAU - Iacoviello, Licia AU - Iacoviello L FAU - Cuomo, Chiara AU - Cuomo C FAU - Latella, Maria Carmela AU - Latella MC FAU - di Giannantonio, Massimo AU - di Giannantonio M FAU - Janiri, Luigi AU - Janiri L FAU - de Gaetano, Monica AU - de Gaetano M FAU - Janal, Malvin N AU - Janal MN LA - eng PT - Comparative Study PT - Journal Article DEP - 20080707 PL - Switzerland TA - Neuropsychobiology JT - Neuropsychobiology JID - 7512895 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adult MH - Adult Survivors of Child Abuse/*psychology MH - Amino Acid Substitution MH - Brain-Derived Neurotrophic Factor/*genetics MH - Chi-Square Distribution MH - Depressive Disorder, Major/*genetics/psychology MH - Female MH - Humans MH - Logistic Models MH - Male MH - Middle Aged MH - Polymorphism, Single Nucleotide MH - Suicide, Attempted/*psychology EDAT- 2008/07/05 09:00 MHDA- 2008/09/16 09:00 CRDT- 2008/07/05 09:00 PHST- 2007/10/29 00:00 [received] PHST- 2008/03/16 00:00 [accepted] PHST- 2008/07/05 09:00 [pubmed] PHST- 2008/09/16 09:00 [medline] PHST- 2008/07/05 09:00 [entrez] AID - 000142361 [pii] AID - 10.1159/000142361 [doi] PST - ppublish SO - Neuropsychobiology. 2008;57(3):139-45. doi: 10.1159/000142361. Epub 2008 Jul 7.