PMID- 18600370
OWN - NLM
STAT- MEDLINE
DCOM- 20090210
LR  - 20211020
IS  - 0172-0643 (Print)
IS  - 0172-0643 (Linking)
VI  - 29
IP  - 6
DP  - 2008 Nov
TI  - Treatment strategies for pediatric patients with primary cardiac and pericardial 
      tumors: a 30-year review.
PG  - 1071-6
LID - 10.1007/s00246-008-9256-6 [doi]
AB  - This study reviewed different types of primary cardiac and mediastinal tumors in 
      infants and children as well as their clinical presentation and management. 
      Altogether, 34 consecutive patients followed from 1976 through December 2005 were 
      analyzed. Of these 34 patients, 14 (41%) underwent surgery and 20 (59%) with 
      rhabdomyomas were managed conservatively. Histologic examination of the 
      surgically resected tumors showed teratoma in four patients, rhabdomyoma in four 
      patients, and hemangioma in two patients. Myxoma, myofibroma, neuroblastoma, and 
      malignant fibrous histiocytoma were encountered in one patient each. Follow-up 
      evaluation was completed for 97% of the patients and extended up to 30 years. 
      Half of the nonsurgical patients with rhabdomyoma showed partial or complete 
      spontaneous regression. One patient died after resection of a malignant 
      histiocytoma, and one patient required a tumor-related reoperation. Freedom from 
      tumor-related reoperation after 10 years was 91% +/- 8.7%. Of the survivors, 85% 
      were New York Heart Association (NYHA) class 1, and 100% had sinus rhythm. 
      Spontaneous tumor regression is common in rhabdomyoma and surgery, and is 
      indicated only for symptomatic patients with hemodynamically significant 
      intracardiac obstruction. For all other benign primary cardiac tumors, complete 
      resection usually can be accomplished with good results. Patients with giant 
      tumor masses compressing or infiltrating the heart frequently cannot undergo 
      complete resection. For these patients, restoration/preservation of sufficient 
      heart function is the primary goal. Malignant tumors are extremely rare in 
      pediatric patients and have a very poor prognosis.
FAU - Gunther, Thomas
AU  - Gunther T
AD  - Department of Cardiovascular Surgery, German Heart Center at the Technical 
      University, Lazarettstrasse, Munich, Germany.
FAU - Schreiber, Christian
AU  - Schreiber C
FAU - Noebauer, Christian
AU  - Noebauer C
FAU - Eicken, Andreas
AU  - Eicken A
FAU - Lange, Ruediger
AU  - Lange R
LA  - eng
PT  - Journal Article
DEP - 20080704
PL  - United States
TA  - Pediatr Cardiol
JT  - Pediatric cardiology
JID - 8003849
SB  - IM
MH  - Adolescent
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - Echocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Neoplasms/pathology/*therapy
MH  - Humans
MH  - Infant
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Mediastinal Neoplasms/pathology/*therapy
MH  - Myxoma/pathology/therapy
MH  - Prognosis
MH  - Reoperation
MH  - Rhabdomyoma/pathology/therapy
MH  - Teratoma/pathology/therapy
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
EDAT- 2008/07/05 09:00
MHDA- 2009/02/12 09:00
CRDT- 2008/07/05 09:00
PHST- 2008/01/16 00:00 [received]
PHST- 2008/06/04 00:00 [accepted]
PHST- 2008/04/19 00:00 [revised]
PHST- 2008/07/05 09:00 [pubmed]
PHST- 2009/02/12 09:00 [medline]
PHST- 2008/07/05 09:00 [entrez]
AID - 10.1007/s00246-008-9256-6 [doi]
PST - ppublish
SO  - Pediatr Cardiol. 2008 Nov;29(6):1071-6. doi: 10.1007/s00246-008-9256-6. Epub 2008 
      Jul 4.