PMID- 18600653
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100520
LR  - 20080707
IS  - 0006-3592 (Print)
IS  - 0006-3592 (Linking)
VI  - 37
IP  - 7
DP  - 1991 Mar 25
TI  - A novel magnetic silica support for use in chromatographic and enzymatic 
      bioprocessing.
PG  - 614-26
AB  - A limited number of support matrices have so far been developed for use in 
      magnetically stabilized fluidized bed (MSFB) applications. We have developed a 
      versatile magnetic silica support which can be derivatized readily for both 
      adsorption chromatography and enzyme immobilization by well-known techniques. A 
      magnetic pellicular bead is prepared by electrostatically depositing alternating 
      layers of colloidal silica and cationic polymer onto macroscopic nickel core 
      particles. The polymer is then burned out and the silica partially sintered to 
      yield a porous shell with 5-80 m(2)/g of surface area. This magnetic composite 
      was tested as a support for immobilizing invertase. Sucrose was continuously 
      converted to its component monosaccharides with nearly constant activity over the 
      first 8 days and retention of 50% of initial activity after 25 days.
FAU - Goetz, V
AU  - Goetz V
AD  - Department of Chemical Engineering, University of Pennsylvania, Philadelphia, 
      Pennsylvania 19104-6393, USA.
FAU - Remaud, M
AU  - Remaud M
FAU - Graves, D J
AU  - Graves DJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biotechnol Bioeng
JT  - Biotechnology and bioengineering
JID - 7502021
EDAT- 1991/03/25 00:00
MHDA- 1991/03/25 00:01
CRDT- 1991/03/25 00:00
PHST- 1991/03/25 00:00 [pubmed]
PHST- 1991/03/25 00:01 [medline]
PHST- 1991/03/25 00:00 [entrez]
AID - 10.1002/bit.260370704 [doi]
PST - ppublish
SO  - Biotechnol Bioeng. 1991 Mar 25;37(7):614-26. doi: 10.1002/bit.260370704.