PMID- 18601957 OWN - NLM STAT- MEDLINE DCOM- 20090112 LR - 20131121 IS - 1872-7549 (Electronic) IS - 0166-4328 (Linking) VI - 195 IP - 1 DP - 2008 Dec 16 TI - Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation. PG - 129-38 LID - 10.1016/j.bbr.2008.06.009 [doi] AB - Increased serotonin (5-hydroxytryptamine, 5-HT) release in the hippocampus induced by repeated stress is thought to be critical for the neuroadaptation that alleviates the adverse effects of stressors on emotion and behavior. A failure in this process may be one of the primary neuropathological mechanisms underlying the development of stress-related disorders. The para-chloroamphetamine (p-PCA) was used to deplete 5-HT in the rat prior to repeated restraint stress (6h/day for 10 days), and determined the consequences of 5-HT depletion on stress-induced alterations of animal behaviors, hippocampal corticosteroid receptor immunoreactivity and the brain-derived neurotrophic factor (BDNF) mRNA expression. Behavioral tests indicate that the stressed rats with 5-HT depletion showed pronounced anxiety, reduced reward sensitivity and enhanced learned-helplessness. In addition, they also developed learning impairments in Morris water maze tests. These results suggest that hippocampal 5-HT depletion compromised adaptation to chronic stress. Furthermore, repeated stress caused a lesser degree of glucocorticoid receptor increase and down-regulation of BDNF mRNA. The study suggest that 5-HT deficiency in the adult hippocampus may impair stress adaptation by suppressing hippocampal GR and BDNF expression. FAU - Zhou, Jiansong AU - Zhou J AD - Mental Health Institute of the 2nd Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha 410011 Hunan, China. FAU - Li, Lingjiang AU - Li L FAU - Tang, Shaojun AU - Tang S FAU - Cao, Xia AU - Cao X FAU - Li, Zexuan AU - Li Z FAU - Li, Weihui AU - Li W FAU - Li, Changqi AU - Li C FAU - Zhang, Xianghui AU - Zhang X LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20080612 PL - Netherlands TA - Behav Brain Res JT - Behavioural brain research JID - 8004872 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (RNA, Messenger) RN - 0 (Receptors, Glucocorticoid) RN - 0 (Receptors, Mineralocorticoid) RN - 0 (Serotonin Agents) RN - 333DO1RDJY (Serotonin) RN - 64-12-0 (p-Chloroamphetamine) SB - IM MH - Analysis of Variance MH - Animals MH - Behavior, Animal/drug effects/physiology MH - Brain-Derived Neurotrophic Factor/*genetics MH - Exploratory Behavior/drug effects/physiology MH - Food Preferences/drug effects/psychology MH - Gene Expression/drug effects MH - Hippocampus/drug effects/*metabolism MH - Immunohistochemistry MH - In Situ Hybridization MH - Male MH - Maze Learning/drug effects/physiology MH - Microinjections MH - Motor Activity/drug effects/physiology MH - RNA, Messenger/genetics/metabolism MH - Rats MH - Rats, Sprague-Dawley MH - Receptors, Glucocorticoid/*metabolism MH - Receptors, Mineralocorticoid/*metabolism MH - Restraint, Physical/methods/psychology MH - Serotonin/deficiency/*metabolism MH - Serotonin Agents/administration & dosage/toxicity MH - Stress, Psychological/*physiopathology MH - p-Chloroamphetamine/administration & dosage/toxicity EDAT- 2008/07/08 09:00 MHDA- 2009/01/13 09:00 CRDT- 2008/07/08 09:00 PHST- 2008/03/10 00:00 [received] PHST- 2008/06/04 00:00 [revised] PHST- 2008/06/04 00:00 [accepted] PHST- 2008/07/08 09:00 [pubmed] PHST- 2009/01/13 09:00 [medline] PHST- 2008/07/08 09:00 [entrez] AID - S0166-4328(08)00307-0 [pii] AID - 10.1016/j.bbr.2008.06.009 [doi] PST - ppublish SO - Behav Brain Res. 2008 Dec 16;195(1):129-38. doi: 10.1016/j.bbr.2008.06.009. Epub 2008 Jun 12.