PMID- 18602381
OWN - NLM
STAT- MEDLINE
DCOM- 20081009
LR  - 20151119
IS  - 1873-2933 (Electronic)
IS  - 0009-9120 (Linking)
VI  - 41
IP  - 13
DP  - 2008 Sep
TI  - Prognostic value of cell-cycle regulators and cellular biomarkers in laryngeal 
      squamous cell carcinoma.
PG  - 1059-66
LID - 10.1016/j.clinbiochem.2008.06.001 [doi]
AB  - OBJECTIVE: Combining information derived from cellular biomarkers as telomerase 
      and genes encoding cyclin dependent kinase inhibitors (p16(INK4a) and p15(INK4b)) 
      is needed to facilitate the stratification of individual patients within the 
      conventional clinicopathologic parameters. DESIGN AND METHODS: One hundred forty 
      laryngeal squamous cell carcinoma (LSCC) tissue specimens were investigated for 
      telomerase activity and the deletions of p16(INK4a) and p15(INK4b) genes. 
      RESULTS: Of the 140 tissues assayed, 71% demonstrated high telomerase activity, 
      68.6% and 80% showed deletions in p16(INK4a) and p15(INK4b) genes, respectively. 
      Significant difference was observed between telomerase activity, p16(INK4a) and 
      p15(INK4b) deletions among each other and with advanced stage, poorly 
      differentiated grades, high proliferation and DNA aneuploidy. The markers and the 
      aforementioned clinicopathological factors were correlated with progression in 
      univariate analysis; and associated with survival in multivariate analysis. 
      CONCLUSION: Progression of LSCC is accompanied by a parallel increase in 
      telomerase activity and deletions in cell-cycle regulators (p16(INK4a), 
      p15(INK4b)) which may assist in prognostication and better classification of 
      patients for treatment.
FAU - Swellam, Menha
AU  - Swellam M
AD  - Department of Biochemistry, Genetic Engineering and Biotechnology Research 
      Division, National Research Center, Tahrir Street, Dokki, Giza 12311, Egypt. 
      menha_m_swellam@yahoo.com
FAU - El-Arab, Lobna R Ezz
AU  - El-Arab LR
FAU - Adly, Ahmed
AU  - Adly A
LA  - eng
PT  - Journal Article
DEP - 20080610
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p15)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - EC 2.7.7.49 (Telomerase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Squamous Cell/*diagnosis/therapy
MH  - Combined Modality Therapy
MH  - Cyclin-Dependent Kinase Inhibitor p15/*genetics
MH  - Cyclin-Dependent Kinase Inhibitor p16/*genetics
MH  - Disease Progression
MH  - Female
MH  - Gene Deletion
MH  - Humans
MH  - Laryngeal Neoplasms/*diagnosis/therapy
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Regression Analysis
MH  - Risk Factors
MH  - Survival Analysis
MH  - Telomerase/*metabolism
EDAT- 2008/07/08 09:00
MHDA- 2008/10/10 09:00
CRDT- 2008/07/08 09:00
PHST- 2007/12/11 00:00 [received]
PHST- 2008/05/01 00:00 [revised]
PHST- 2008/06/01 00:00 [accepted]
PHST- 2008/07/08 09:00 [pubmed]
PHST- 2008/10/10 09:00 [medline]
PHST- 2008/07/08 09:00 [entrez]
AID - S0009-9120(08)00221-X [pii]
AID - 10.1016/j.clinbiochem.2008.06.001 [doi]
PST - ppublish
SO  - Clin Biochem. 2008 Sep;41(13):1059-66. doi: 10.1016/j.clinbiochem.2008.06.001. 
      Epub 2008 Jun 10.