PMID- 18602452
OWN - NLM
STAT- MEDLINE
DCOM- 20081014
LR  - 20220408
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 442
IP  - 1
DP  - 2008 Sep 5
TI  - The BDNF Val66Met polymorphism and smoking.
PG  - 30-3
LID - 10.1016/j.neulet.2008.06.064 [doi]
AB  - Although the brain derived neurotrophic factor (BDNF) has been mainly 
      investigated in the context of depression and anxiety disorders, several studies 
      also suggest an association between BDNF and smoking. BDNF represents a protein 
      which crucially influences several processes in the cell ranging from growth to 
      apoptosis. A functional variant of the BDNF gene - the BDNF Val66Met polymorphism 
      - is one of the main targets in BDNF research because of its influence on BDNF 
      secretion. Recently an association between the 66Met allele and smoking has been 
      reported in a sample of 320 Caucasians. The aim of the present study was to 
      replicate this association in a sample nearly twice as large consisting of N=614 
      German Caucasian participants. A link between smoking and the BDNF Val66Met 
      polymorphism could not be found in our data.
FAU - Montag, Christian
AU  - Montag C
AD  - Department of Psychology, University of Bonn, Kaiser-Karl-Ring 9, D-53111 Bonn, 
      Germany. christian.montag@uni-bonn-diff.de
FAU - Basten, Ulrike
AU  - Basten U
FAU - Stelzel, Christine
AU  - Stelzel C
FAU - Fiebach, Christian J
AU  - Fiebach CJ
FAU - Reuter, Martin
AU  - Reuter M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080627
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Behavior, Addictive/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide
MH  - Smoking/*genetics
EDAT- 2008/07/08 09:00
MHDA- 2008/10/15 09:00
CRDT- 2008/07/08 09:00
PHST- 2008/05/02 00:00 [received]
PHST- 2008/06/24 00:00 [revised]
PHST- 2008/06/24 00:00 [accepted]
PHST- 2008/07/08 09:00 [pubmed]
PHST- 2008/10/15 09:00 [medline]
PHST- 2008/07/08 09:00 [entrez]
AID - S0304-3940(08)00916-6 [pii]
AID - 10.1016/j.neulet.2008.06.064 [doi]
PST - ppublish
SO  - Neurosci Lett. 2008 Sep 5;442(1):30-3. doi: 10.1016/j.neulet.2008.06.064. Epub 
      2008 Jun 27.