PMID- 18602732 OWN - NLM STAT- MEDLINE DCOM- 20081022 LR - 20080729 IS - 0278-5846 (Print) IS - 0278-5846 (Linking) VI - 32 IP - 6 DP - 2008 Aug 1 TI - No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and tardive dyskinesia in schizophrenic patients. PG - 1545-8 LID - 10.1016/j.pnpbp.2008.05.016 [doi] AB - OBJECTIVE: This study investigated whether the brain-derived neurotrophic factor (BDNF) gene Val66Met single-nucleotide polymorphism (SNP) is associated with antipsychotic-induced tardive dyskinesia (TD) in schizophrenia. METHODS: Genotyping was performed for the BDNF gene Val66Met SNP in Korean schizophrenic patients with (n=83) and without TD (n=126) who were matched for antipsychotic drug exposure and other relevant variables. RESULTS: The frequencies of genotypes (chi2=2.37, p=0.306) and alleles (chi2=0.03, p=0.867) did not differ significantly between these two groups. CONCLUSION: These findings suggest that the BDNF polymorphism does not play a major role in the susceptibility to TD in schizophrenic patients. FAU - Kang, Seung-Gul AU - Kang SG AD - Department of Psychiatry, Korea University College of Medicine, and Kangbuk Samsung Hospital, Seoul, South Korea. FAU - Choi, Jung-Eun AU - Choi JE FAU - An, Hyonggin AU - An H FAU - Lim, Se-Won AU - Lim SW FAU - Lee, Heon-Jeong AU - Lee HJ FAU - Han, Changsu AU - Han C FAU - Kim, Yong-Ku AU - Kim YK FAU - Kim, Seung-Hyun AU - Kim SH FAU - Cho, Sung Nam AU - Cho SN FAU - Lee, Min-Soo AU - Lee MS FAU - Joe, Sook-Haeng AU - Joe SH FAU - Jung, In-Kwa AU - Jung IK FAU - Kim, Leen AU - Kim L LA - eng PT - Journal Article DEP - 20080529 PL - England TA - Prog Neuropsychopharmacol Biol Psychiatry JT - Progress in neuro-psychopharmacology & biological psychiatry JID - 8211617 RN - 0 (Antipsychotic Agents) RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adult MH - Alleles MH - Amino Acid Substitution MH - Antipsychotic Agents/adverse effects MH - Brain-Derived Neurotrophic Factor/*genetics MH - Dyskinesia, Drug-Induced/*genetics MH - Female MH - Gene Frequency MH - Genotype MH - Humans MH - Male MH - Middle Aged MH - Mutation/physiology MH - Polymorphism, Genetic/*genetics MH - Schizophrenia/complications/drug therapy/*genetics EDAT- 2008/07/08 09:00 MHDA- 2008/10/23 09:00 CRDT- 2008/07/08 09:00 PHST- 2008/02/28 00:00 [received] PHST- 2008/05/15 00:00 [revised] PHST- 2008/05/22 00:00 [accepted] PHST- 2008/07/08 09:00 [pubmed] PHST- 2008/10/23 09:00 [medline] PHST- 2008/07/08 09:00 [entrez] AID - S0278-5846(08)00151-6 [pii] AID - 10.1016/j.pnpbp.2008.05.016 [doi] PST - ppublish SO - Prog Neuropsychopharmacol Biol Psychiatry. 2008 Aug 1;32(6):1545-8. doi: 10.1016/j.pnpbp.2008.05.016. Epub 2008 May 29.