PMID- 18602983
OWN - NLM
STAT- MEDLINE
DCOM- 20081209
LR  - 20221207
IS  - 1089-8646 (Electronic)
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 92
IP  - 4
DP  - 2008 Oct
TI  - Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 
      20q13.1.
PG  - 226-34
LID - 10.1016/j.ygeno.2008.06.004 [doi]
AB  - Human chromosome 20q12-q13.1 has been linked to type 2 diabetes mellitus (T2DM) 
      in multiple studies. We screened a 5.795-Mb region for diabetes-related 
      susceptibility genes in a Caucasian cohort of 310 controls and 300 cases with 
      T2DM and end-stage renal disease (ESRD), testing 390 SNPs for association with 
      T2DM-ESRD. The most significant SNPs were found in the perigenic regions: HNF4A 
      (hepatocyte nuclear factor 4alpha), SLC12A5 (potassium-chloride cotransporter 
      member 5), CDH22 (cadherin-like 22), ELMO2 (engulfment and cell motility 2), 
      SLC13A3 (sodium-dependent dicarboxylate transporter member 3), and PREX1 
      (phosphatidylinositol 3,4,5-triphosphate-dependent RAC exchanger 1). Haplotype 
      analysis found six haplotype blocks globally associated with disease (p<0.05). We 
      replicated the PREX1 SNP association in an independent case-control T2DM 
      population and inferred replication of CDH22, ELMO2, SLC13A3, SLC12A5, and PREX1 
      using in silico perigenic analysis of two T2DM Genome-Wide Association Study data 
      sets. We found substantial heterogeneity between study results.
FAU - Bento, J L
AU  - Bento JL
AD  - Department of Biochemistry, Wake Forest University School of Medicine, 
      Winston-Salem, NC 27157, USA.
FAU - Palmer, N D
AU  - Palmer ND
FAU - Zhong, M
AU  - Zhong M
FAU - Roh, B
AU  - Roh B
FAU - Lewis, J P
AU  - Lewis JP
FAU - Wing, M R
AU  - Wing MR
FAU - Pandya, H
AU  - Pandya H
FAU - Freedman, B I
AU  - Freedman BI
FAU - Langefeld, C D
AU  - Langefeld CD
FAU - Rich, S S
AU  - Rich SS
FAU - Bowden, D W
AU  - Bowden DW
FAU - Mychaleckyj, J C
AU  - Mychaleckyj JC
LA  - eng
GR  - R01 DK056289/DK/NIDDK NIH HHS/United States
GR  - R01 DK056289-07/DK/NIDDK NIH HHS/United States
GR  - R01 DK056289-08/DK/NIDDK NIH HHS/United States
GR  - R01 DK56289/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080809
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Cadherins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (ELMO2 protein, human)
RN  - 0 (Guanine Nucleotide Exchange Factors)
RN  - 0 (PREX1 protein, human)
RN  - 177646-56-9 (CDH22 protein, human)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/genetics
MH  - Cadherins/genetics
MH  - Case-Control Studies
MH  - Chromosomes, Human, Pair 20/*genetics
MH  - Cytoskeletal Proteins/genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Diabetic Nephropathies/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Guanine Nucleotide Exchange Factors/genetics
MH  - Humans
MH  - Kidney Failure, Chronic/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Quantitative Trait Loci/*genetics
MH  - White People/genetics
PMC - PMC2583938
MID - NIHMS72611
EDAT- 2008/07/08 09:00
MHDA- 2008/12/17 09:00
PMCR- 2009/10/01
CRDT- 2008/07/08 09:00
PHST- 2008/01/07 00:00 [received]
PHST- 2008/04/11 00:00 [revised]
PHST- 2008/06/04 00:00 [accepted]
PHST- 2008/07/08 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/07/08 09:00 [entrez]
PHST- 2009/10/01 00:00 [pmc-release]
AID - S0888-7543(08)00137-7 [pii]
AID - 10.1016/j.ygeno.2008.06.004 [doi]
PST - ppublish
SO  - Genomics. 2008 Oct;92(4):226-34. doi: 10.1016/j.ygeno.2008.06.004. Epub 2008 Aug 
      9.