PMID- 18603005
OWN - NLM
STAT- MEDLINE
DCOM- 20081229
LR  - 20141120
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 42
IP  - 4
DP  - 2008 Oct 1
TI  - The BDNF Val66Met polymorphism affects amygdala activity in response to emotional 
      stimuli: evidence from a genetic imaging study.
PG  - 1554-9
LID - 10.1016/j.neuroimage.2008.06.008 [doi]
AB  - Mounting evidence shows that the brain derived neurotrophic factor (BDNF) plays a 
      crucial role in synaptic plasticity. Due to its potential involvement in 
      psychiatric diseases like depression and anxiety disorders BDNF lately became a 
      major target in research. A functional variant of the BDNF gene--the BDNF 
      Val66Met polymorphism--is of particular interest, because it influences the BDNF 
      secretion which is followed by signaling at the TrkB receptor leading to 
      dendritic growth of neurons. Findings from genetic association studies in humans 
      yield heterogenous results with respect to the question of which allele 
      represents a potential risk factor for an affective disorder. Although structural 
      MRT studies revealed that the 66Met variant is associated with smaller hippocampi 
      and could therefore present the risk allele, fMRI studies investigating the 
      processing of emotion with respect to the BDNF Val66Met polymorphism are lacking. 
      N=37 healthy female subjects participated in an fMRI experiment with an affective 
      startle reflex paradigm. Carriers of the 66Met variant showed stronger amygdala 
      activation in the right hemisphere in response to emotional stimuli compared to 
      neutral stimuli. The results of this study add to growing literature, showing 
      that it is the 66Met, which is associated with higher trait anxiety.
FAU - Montag, Christian
AU  - Montag C
AD  - Department of Psychology, University of Bonn, Kaiser-Karl-Ring 9 D-53111 Bonn, 
      Germany. christian.montag@uni-bonn-diff.de
FAU - Reuter, Martin
AU  - Reuter M
FAU - Newport, Beate
AU  - Newport B
FAU - Elger, Christian
AU  - Elger C
FAU - Weber, Bernd
AU  - Weber B
LA  - eng
PT  - Journal Article
DEP - 20080618
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Amygdala/*physiology
MH  - Brain Mapping/methods
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Emotions/*physiology
MH  - Evoked Potentials/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Reflex, Startle/*physiology
MH  - Young Adult
EDAT- 2008/07/08 09:00
MHDA- 2008/12/30 09:00
CRDT- 2008/07/08 09:00
PHST- 2008/03/14 00:00 [received]
PHST- 2008/06/05 00:00 [revised]
PHST- 2008/06/10 00:00 [accepted]
PHST- 2008/07/08 09:00 [pubmed]
PHST- 2008/12/30 09:00 [medline]
PHST- 2008/07/08 09:00 [entrez]
AID - S1053-8119(08)00754-4 [pii]
AID - 10.1016/j.neuroimage.2008.06.008 [doi]
PST - ppublish
SO  - Neuroimage. 2008 Oct 1;42(4):1554-9. doi: 10.1016/j.neuroimage.2008.06.008. Epub 
      2008 Jun 18.