PMID- 18603624
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20171116
IS  - 1522-9645 (Electronic)
IS  - 0195-668X (Linking)
VI  - 29
IP  - 17
DP  - 2008 Sep
TI  - Epidermal fatty-acid-binding protein: a new circulating biomarker associated with 
      cardio-metabolic risk factors and carotid atherosclerosis.
PG  - 2156-63
LID - 10.1093/eurheartj/ehn295 [doi]
AB  - AIMS: Epidermal fatty-acid-binding protein (E-FABP) is highly homologous to 
      adipocyte FABP (A-FABP), which mediates obesity-related metabolic syndrome 
      (MetS), diabetes and atherosclerosis in animals. Combined deficiency of E-FABP 
      and A-FABP protects against the MetS and atherosclerosis in mice. This study 
      investigated the association of serum E-FABP with cardio-metabolic risk factors 
      and carotid atherosclerosis in humans. METHODS AND RESULTS: The presence of 
      E-FABP in human plasma was detected by tandem mass spectrometry. Serum E-FABP 
      levels, determined by an enzyme-linked immunosorbent assay in 479 Chinese 
      subjects (age: 55.4 +/- 13.5 years; M/F: 232/247), correlated positively (P < 0.05 
      to <0.001, age-adjusted) with parameters of adiposity, adverse lipid profiles, 
      serum insulin, A-FABP, and C-reactive protein levels and were higher in subjects 
      with the MetS (P < 0.001 vs. no MetS). The association of E-FABP with the MetS 
      was independent of A-FABP. Furthermore, serum E-FABP correlated with carotid 
      intima-media thickness (IMT; P < 0.001) and was independently associated with 
      carotid IMT in men (adjusted P = 0.03). CONCLUSION: E-FABP is a new circulating 
      biomarker associated with increased cardio-metabolic risk. It may contribute to 
      the development of the MetS and carotid atherosclerosis in humans, independent of 
      the effect of A-FABP.
FAU - Yeung, Dennis C Y
AU  - Yeung DC
AD  - Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, 
      Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China.
FAU - Wang, Yu
AU  - Wang Y
FAU - Xu, Aimin
AU  - Xu A
FAU - Cheung, Stephen C W
AU  - Cheung SC
FAU - Wat, Nelson M S
AU  - Wat NM
FAU - Fong, Daniel Y T
AU  - Fong DY
FAU - Fong, Carol H Y
AU  - Fong CH
FAU - Chau, M T
AU  - Chau MT
FAU - Sham, Pak C
AU  - Sham PC
FAU - Lam, Karen S L
AU  - Lam KS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080704
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
RN  - 0 (Biomarkers)
RN  - 0 (FABP5 protein, human)
RN  - 0 (Fatty Acid-Binding Proteins)
SB  - IM
MH  - Adiposity/physiology
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Carotid Artery Diseases/*diagnosis
MH  - Carotid Intima-Media Thickness
MH  - Fatty Acid-Binding Proteins/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/blood
MH  - Middle Aged
MH  - Obesity/blood
MH  - Risk Factors
EDAT- 2008/07/08 09:00
MHDA- 2011/12/13 00:00
CRDT- 2008/07/08 09:00
PHST- 2008/07/08 09:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PHST- 2008/07/08 09:00 [entrez]
AID - ehn295 [pii]
AID - 10.1093/eurheartj/ehn295 [doi]
PST - ppublish
SO  - Eur Heart J. 2008 Sep;29(17):2156-63. doi: 10.1093/eurheartj/ehn295. Epub 2008 
      Jul 4.