PMID- 18603777
OWN - NLM
STAT- MEDLINE
DCOM- 20080922
LR  - 20131121
IS  - 1347-6947 (Electronic)
IS  - 0916-8451 (Linking)
VI  - 72
IP  - 7
DP  - 2008 Jul
TI  - Dietary alpha-linked galacto-oligosaccharide suppresses ovalbumin-induced 
      allergic peritonitis in BALB/c mice.
PG  - 1901-7
AB  - To determine whether alpha-linked galacto-oligosaccharide (alpha-GOS) prevents 
      allergic peritonitis, BALB/c mice were fed a synthetic diet with and without 
      alpha-GOS supplementation for 7 d, and were then subcutaneously immunized with 
      ovalbumin on days 0 and 7. The mice were challenged by intraperitoneal injection 
      with ovalbumin on day 14, followed by peritoneal lavage on day 15. The total 
      number of peritoneal exudate cells was significantly lower in the mice fed the 
      alpha-GOS diet than in those fed the control diet. Peritoneal lavage fluid from 
      mice fed the alpha-GOS diet not only had less potency to attract peripheral blood 
      leukocytes and peritoneal exudate cells ex vivo, but also had lower 
      concentrations of monocyte chemoattractant protein-1 (MCP-1) and eotaxin. 
      Preincubation of the cells with alpha-GOS failed to affect the migration to 
      peritoneal lavage fluid. We propose that dietary alpha-GOS reduces cell 
      infiltration in allergic peritonitis by reducing antigen-induced elicitation of 
      MCP-1 and eotaxin in mice.
FAU - Pirapatdit, Sooksan
AU  - Pirapatdit S
AD  - Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School 
      of Agriculture, Hokkaido University, Sapporo, Japan.
FAU - Kishino, Eriko
AU  - Kishino E
FAU - Fujita, Koki
AU  - Fujita K
FAU - Hashimoto, Hiroyuki
AU  - Hashimoto H
FAU - Mori, Shigeharu
AU  - Mori S
FAU - Saito, Sanshiro
AU  - Saito S
FAU - Sato, Toshiro
AU  - Sato T
FAU - Watanabe, Jun
AU  - Watanabe J
FAU - Sonoyama, Kei
AU  - Sonoyama K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080707
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL11)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Oligosaccharides)
RN  - 9006-59-1 (Ovalbumin)
RN  - X2RN3Q8DNE (Galactose)
SB  - IM
MH  - Animals
MH  - Ascitic Fluid/immunology/pathology
MH  - Cell Movement/drug effects
MH  - Chemokine CCL11/analysis
MH  - Chemokine CCL2/analysis
MH  - Dietary Supplements
MH  - Galactose
MH  - Hypersensitivity/*drug therapy/etiology
MH  - Leukocytes
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Oligosaccharides/administration & dosage/*pharmacology/therapeutic use
MH  - Ovalbumin/administration & dosage/adverse effects
MH  - Peritonitis/*drug therapy/etiology/immunology/pathology
EDAT- 2008/07/08 09:00
MHDA- 2008/09/23 09:00
CRDT- 2008/07/08 09:00
PHST- 2008/07/08 09:00 [pubmed]
PHST- 2008/09/23 09:00 [medline]
PHST- 2008/07/08 09:00 [entrez]
AID - JST.JSTAGE/bbb/80155 [pii]
AID - 10.1271/bbb.80155 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 2008 Jul;72(7):1901-7. doi: 10.1271/bbb.80155. Epub 
      2008 Jul 7.