PMID- 18604298
OWN - NLM
STAT- MEDLINE
DCOM- 20081030
LR  - 20240323
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2008
DP  - 2008
TI  - Effect of prenatal protein malnutrition on long-term potentiation and BDNF 
      protein expression in the rat entorhinal cortex after neocortical and hippocampal 
      tetanization.
PG  - 646919
LID - 10.1155/2008/646919 [doi]
LID - 646919
AB  - Reduction of the protein content from 25 to 8% casein in the diet of pregnant 
      rats results in impaired neocortical long-term potentiation (LTP) of the 
      offspring together with lower visuospatial memory performance. The present study 
      was aimed to investigate whether this type of maternal malnutrition could result 
      in modification of plastic capabilities of the entorhinal cortex (EC) in the 
      adult progeny. Unlike normal eutrophic controls, 55-60-day-old prenatally 
      malnourished rats were unable to develop LTP in the medial EC to tetanizing 
      stimulation delivered to either the ipsilateral occipital cortex or the CA1 
      hippocampal region. Tetanizing stimulation of CA1 also failed to increase the 
      concentration of brain-derived neurotrophic factor (BDNF) in the EC of 
      malnourished rats. Impaired capacity of the EC of prenatally malnourished rats to 
      develop LTP and to increase BDNF levels during adulthood may be an important 
      factor contributing to deficits in learning performance having adult prenatally 
      malnourished animals.
FAU - Hernandez, Alejandro
AU  - Hernandez A
AD  - Department of Biology, Faculty of Chemistry and Biology, University of Santiago 
      of Chile, 3363 Avenida Alameda Bernardo O'Higgins, 9170022 Santiago, Chile. 
      ahernand@lauca.usach.cl
FAU - Burgos, Hector
AU  - Burgos H
FAU - Mondaca, Mauricio
AU  - Mondaca M
FAU - Barra, Rafael
AU  - Barra R
FAU - Nunez, Hector
AU  - Nunez H
FAU - Perez, Hernan
AU  - Perez H
FAU - Soto-Moyano, Ruben
AU  - Soto-Moyano R
FAU - Sierralta, Walter
AU  - Sierralta W
FAU - Fernandez, Victor
AU  - Fernandez V
FAU - Olivares, Ricardo
AU  - Olivares R
FAU - Valladares, Luis
AU  - Valladares L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis/deficiency
MH  - Entorhinal Cortex/growth & development/metabolism
MH  - Female
MH  - Gene Expression Regulation, Developmental/physiology
MH  - Hippocampus/growth & development/*metabolism
MH  - Learning Disabilities/metabolism/physiopathology
MH  - Long-Term Potentiation/*physiology
MH  - Male
MH  - Malnutrition/metabolism
MH  - Neocortex/growth & development/*metabolism
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/metabolism/*physiopathology
MH  - Protein Deficiency/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC2442167
EDAT- 2008/07/08 09:00
MHDA- 2008/10/31 09:00
PMCR- 2008/06/30
CRDT- 2008/07/08 09:00
PHST- 2008/02/05 00:00 [received]
PHST- 2008/05/30 00:00 [accepted]
PHST- 2008/07/08 09:00 [pubmed]
PHST- 2008/10/31 09:00 [medline]
PHST- 2008/07/08 09:00 [entrez]
PHST- 2008/06/30 00:00 [pmc-release]
AID - 10.1155/2008/646919 [doi]
PST - ppublish
SO  - Neural Plast. 2008;2008:646919. doi: 10.1155/2008/646919.