PMID- 18604546
OWN - NLM
STAT- MEDLINE
DCOM- 20090505
LR  - 20220331
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 266
IP  - 2
DP  - 2009 Feb
TI  - The influence of laryngopharyngeal reflux in the healing of laryngeal trauma.
PG  - 253-9
LID - 10.1007/s00405-008-0744-3 [doi]
AB  - The aim of this clinical study was to evaluate the effect of laryngopharyngeal 
      reflux (LPR) on the healing process of surgical laryngeal trauma. A total of 112 
      consecutive patients, who suffered from LPR and were scheduled for operation of 
      Reinke edema or laryngeal polyps/nodules (40 and 72 patients, respectively) 
      during a period of 5 years, were included. Diagnosis of LPR was made on the basis 
      of both history and dual pH probe recording during 24 h in the inferior esophagus 
      and the hypopharynx. The reflux finding score (RFS) and the reflux symptom index 
      (RSI) were used to estimate the clinical severity of LPR. In patients with LPR, 
      proton pump inhibitors (PPI) were initiated in half of them, randomly chosen. 
      Fifty LPR-free subjects operated for Reinke edema or laryngeal polyps during the 
      same time period (19 and 31 patients, respectively) were used as controls. In six 
      patients who had been administered PPI, resolution of the disease was observed 
      and no surgical treatment was undertaken. The remaining patients were operated on 
      under general anesthesia by a single surgeon. All patients had 1-year 
      postoperative follow-up. Epithelization was complete in all vocal cords of both 
      the control group and the group of patients who had been administered PPI. Within 
      the group of patients who had not taken PPI, six patients presented granulation 
      tissue or recurrence of the polyps and in two of them revision surgery was 
      needed. RFS and RSI scores showed significant improvement postoperatively, across 
      all the three groups of patients, with major differences observed in the group 
      treated by PPI. Comparison of the postoperative RFS and RSI scores between the 
      two groups of patients with LPR showed statistically significant differences in 
      both, indicating better treatment outcome in those patients who had received PPI. 
      It may be thus concluded that LPR influences epithelization and recurrence of 
      laryngeal polyps or Reinke edema in vocal cords, after partial or total 
      decortication. Surgical outcome is superior in patients with LPR with 
      preoperative and postoperative anti-reflux treatment.
FAU - Kantas, Ilias
AU  - Kantas I
AD  - ENT Department, G.Genimmatas General hospital, Thessaloniki, Greece.
FAU - Balatsouras, Dimitrios G
AU  - Balatsouras DG
FAU - Kamargianis, Nikolaos
AU  - Kamargianis N
FAU - Katotomichelakis, Michael
AU  - Katotomichelakis M
FAU - Riga, Maria
AU  - Riga M
FAU - Danielidis, Vasilis
AU  - Danielidis V
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20080705
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Gastroesophageal Reflux/complications/diagnosis/*drug therapy
MH  - Humans
MH  - Hypopharynx/*drug effects/pathology/surgery
MH  - Laryngeal Diseases/complications/pathology/surgery
MH  - Laryngeal Edema/complications/diagnosis/*surgery
MH  - Laryngoscopy/methods
MH  - Male
MH  - Middle Aged
MH  - Polyps/complications/pathology/*surgery
MH  - Postoperative Care
MH  - Postoperative Complications/physiopathology/prevention & control
MH  - Preoperative Care/methods
MH  - Probability
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Reference Values
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
MH  - Vocal Cords/drug effects/pathology
MH  - Wound Healing/*drug effects/physiology
EDAT- 2008/07/08 09:00
MHDA- 2009/05/06 09:00
CRDT- 2008/07/08 09:00
PHST- 2007/12/22 00:00 [received]
PHST- 2008/06/02 00:00 [accepted]
PHST- 2008/07/08 09:00 [entrez]
PHST- 2008/07/08 09:00 [pubmed]
PHST- 2009/05/06 09:00 [medline]
AID - 10.1007/s00405-008-0744-3 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2009 Feb;266(2):253-9. doi: 10.1007/s00405-008-0744-3. 
      Epub 2008 Jul 5.