PMID- 18607244
OWN - NLM
STAT- MEDLINE
DCOM- 20081113
LR  - 20090528
IS  - 1558-2027 (Print)
IS  - 1558-2027 (Linking)
VI  - 9
IP  - 8
DP  - 2008 Aug
TI  - Hemodynamic changes before acute heart failure episodes in patients with advanced 
      systolic left ventricular dysfunction.
PG  - 799-804
LID - 10.2459/JCM.0b013e3282f7301d [doi]
AB  - AIM: We sought to verify which changes in right ventricular pressures occur 
      before acute heart failure (HF) in patients with advanced systolic left 
      ventricular (LV) dysfunction. In patients with chronic HF, continuous hemodynamic 
      monitoring by implantable devices may detect increases in pulmonary pressures 
      before the onset of symptoms. METHODS: A device which allowed monitoring of right 
      ventricular systolic (RVSP) and diastolic pressure (RVDP) and an estimate of 
      pulmonary artery diastolic pressure (ePAD) was implanted in 10 patients with 
      advanced LV systolic dysfunction and frequent cardiovascular hospitalizations 
      [mean age 56.8 years; New York Heart Association (NYHA) classes IIIb-IV; LV 
      ejection fraction at echocardiography 21 +/- 2%]. RESULTS: During a follow-up 
      period of 15 +/- 12 months, 18 hospitalizations due to acute HF were recorded; 10 
      episodes were characterized by symptoms due to low-cardiac output (LCO) and eight 
      episodes were characterized by symptoms due to pulmonary congestion. RVSP and 
      ePAD increased before six hospitalizations and decreased before three episodes; 
      RVDP increased before 10 hospitalizations and decreased before one. The extent of 
      RVDP increase was 16 +/- 24% before pulmonary congestion episodes and 29 +/- 32% 
      before LCO episodes. CONCLUSION: An increase in RVDP was the most frequent 
      hemodynamic change detected by the implantable hemodynamic monitor before 
      hospitalizations due to acute HF in patients having advanced systolic LV 
      dysfunction.
FAU - Ghio, Stefano
AU  - Ghio S
AD  - Fondazione IRCCS S. Matteo Hospital, Cardiology Division, Pavia, Italy. 
      s.ghio@smatteo.pv.it
FAU - Serio, Alessandra
AU  - Serio A
FAU - Mangiavacchi, Maurizio
AU  - Mangiavacchi M
FAU - Kjellstrom, Barbro
AU  - Kjellstrom B
FAU - Valsecchi, Sergio
AU  - Valsecchi S
FAU - Vicini, Ilaria
AU  - Vicini I
FAU - Campana, Carlo
AU  - Campana C
FAU - Gasparini, Maurizio
AU  - Gasparini M
FAU - Gronda, Edoardo
AU  - Gronda E
FAU - Tavazzi, Luigi
AU  - Tavazzi L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - J Cardiovasc Med (Hagerstown)
JT  - Journal of cardiovascular medicine (Hagerstown, Md.)
JID - 101259752
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Diagnostic Techniques, Cardiovascular/instrumentation
MH  - Disease Progression
MH  - Electrodes, Implanted
MH  - Follow-Up Studies
MH  - Heart Failure/etiology/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction/*physiology
MH  - Prognosis
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Stroke Volume/*physiology
MH  - Systole
MH  - Ventricular Dysfunction, Left/*complications/physiopathology
MH  - Ventricular Pressure/*physiology
EDAT- 2008/07/09 09:00
MHDA- 2008/11/14 09:00
CRDT- 2008/07/09 09:00
PHST- 2008/07/09 09:00 [pubmed]
PHST- 2008/11/14 09:00 [medline]
PHST- 2008/07/09 09:00 [entrez]
AID - 01244665-200808000-00007 [pii]
AID - 10.2459/JCM.0b013e3282f7301d [doi]
PST - ppublish
SO  - J Cardiovasc Med (Hagerstown). 2008 Aug;9(8):799-804. doi: 
      10.2459/JCM.0b013e3282f7301d.