PMID- 18609140
OWN - NLM
STAT- MEDLINE
DCOM- 20090206
LR  - 20201209
IS  - 1502-7708 (Electronic)
IS  - 0036-5521 (Linking)
VI  - 43
IP  - 10
DP  - 2008
TI  - IL-1beta and IL-8, matrix metalloproteinase 3, and pepsinogen secretion before 
      and after H. pylori eradication in gastroduodenal phenotypes.
PG  - 1184-93
LID - 10.1080/00365520802130209 [doi]
AB  - OBJECTIVE: Relations between host genetic factors and clinical outcomes of 
      Helicobacter pylori infection are variable among ethnicities. The aim of this 
      study was to examine gastric mucosal cytokines, matrix metalloproteinase 3 
      (MMP-3), and serum pepsinogen levels before and after eradication of H. pylori 
      according to IL-1B genotypes and benign gastroduodenal phenotypes in a Korean 
      population. MATERIAL AND METHODS: A total of 349 Koreans including H. 
      pylori-infected subjects (n=230) and H. pylori-negative controls (n=119) were 
      enrolled. The former subjects were classified into groups according to the 
      presence of non-atrophic gastritis (n=74), atrophic gastritis (n=56), gastric 
      ulcer (n=37), and duodenal ulcer (n=63). IL-1B polymorphisms were genotyped by 
      polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). 
      Gastric mucosal IL-1beta, IL-8, and MMP-3, and serum pepsinogen I and II levels 
      were measured by ELISA and radioimmunoassay, respectively. RESULTS: There were no 
      significant differences between the IL-1B-31/-511 haplotype (TT/CC, CT/CT, and 
      CC/TT) frequencies among the H. pylori-positive and -negative groups. The 
      genotypes of IL-1B-31/-511 polymorphisms did not affect clinical phenotypes, 
      inflammatory cytokines, MMP-3, and pepsinogen secretion. Subjects with H. 
      pylori-infected atrophic gastritis exhibited significantly higher basal levels of 
      cytokines and a lower pepsinogen I/II ratio than those of other groups. Following 
      H. pylori eradication, inflammatory cytokines significantly decreased and the 
      pepsinogen I/II ratio increased in all groups. CONCLUSIONS: Mucosal inflammatory 
      cytokines, MMP-3, and pepsinogen secretion are related to gastroduodenal 
      phenotypes but not to IL-1B genotypes. Eradication of H. pylori can reduce 
      mucosal inflammation and restore pepsinogen secretion.
FAU - Chang, Young Woon
AU  - Chang YW
AD  - Department of Gastroenterology, Kyung Hee University College of Medicine, Seoul, 
      Korea.
FAU - Oh, Hyoung-Chul
AU  - Oh HC
FAU - Jang, Jae Young
AU  - Jang JY
FAU - Hwangbo, Young
AU  - Hwangbo Y
FAU - Lee, Jae Won
AU  - Lee JW
FAU - Lee, Hyo Jung
AU  - Lee HJ
FAU - Joo, Kwang Ro
AU  - Joo KR
FAU - Dong, Seok Ho
AU  - Dong SH
FAU - Kim, Sung Soo
AU  - Kim SS
FAU - Kim, Hyo Jong
AU  - Kim HJ
FAU - Kim, Byung Ho
AU  - Kim BH
FAU - Chang, Rin
AU  - Chang R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Gastroenterol
JT  - Scandinavian journal of gastroenterology
JID - 0060105
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-8)
RN  - 9001-10-9 (Pepsinogen A)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - Gastric Mucosa/*metabolism/microbiology/*pathology
MH  - Haplotypes
MH  - Helicobacter Infections/drug therapy/*genetics
MH  - *Helicobacter pylori
MH  - Humans
MH  - Interleukin-1beta/metabolism
MH  - Interleukin-8/metabolism
MH  - Korea
MH  - Male
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Middle Aged
MH  - Pepsinogen A/*metabolism
MH  - Phenotype
MH  - Polymorphism, Genetic
EDAT- 2008/07/09 09:00
MHDA- 2009/02/07 09:00
CRDT- 2008/07/09 09:00
PHST- 2008/07/09 09:00 [pubmed]
PHST- 2009/02/07 09:00 [medline]
PHST- 2008/07/09 09:00 [entrez]
AID - 793240331 [pii]
AID - 10.1080/00365520802130209 [doi]
PST - ppublish
SO  - Scand J Gastroenterol. 2008;43(10):1184-93. doi: 10.1080/00365520802130209.