PMID- 18612668
OWN - NLM
STAT- MEDLINE
DCOM- 20090213
LR  - 20220316
IS  - 1435-4373 (Electronic)
IS  - 0934-9723 (Linking)
VI  - 27
IP  - 11
DP  - 2008 Nov
TI  - Successful control of a hospital-wide vancomycin-resistant Enterococcus faecium 
      outbreak in France.
PG  - 1061-4
LID - 10.1007/s10096-008-0544-0 [doi]
AB  - We describe the control of a hospital-wide vancomycin-resistant Enterococcus 
      faecium (VRE) outbreak in a 2,000-bed university hospital located on three 
      different sites in Clermont-Ferrand, France. From January 2004 to April 2007, 220 
      VRE cases were identified. Overall, 28 different wards had at least one case. All 
      of the strains expressed a high level of resistance to vancomycin and to 
      teicoplanin carried by the vanA gene. Pulsed-field gel electrophoresis (PFGE) 
      analysis of the strains revealed that they were clonally related. Control 
      measures consisted of implementing a strategy of VRE screening by rectal swab, 
      reinforcing hand hygiene practices and taking contact precautions. 
      Recommendations for a restricted use of specific antibiotics were sent to each 
      physician. Alcohol-based handrubs were provided throughout the hospital and the 
      staff underwent training for their use. Compliance with contact precautions, 
      including the use of clean non-sterile gloves and single-use gowns, was 
      reinforced. VRE cases were assigned systematically to a single-bed room. In 
      October 2007, no new VRE carriage has been detected for 7 months and no clinical 
      samples had been VRE-positive for 10 months. In conclusion, a hospital-wide VRE 
      outbreak was successfully controlled by a strategy based on routine screening, 
      the reinforcement of hand hygiene and taking barrier precautions.
FAU - Aumeran, C
AU  - Aumeran C
AD  - Universite Clermont1, Centre Hospitalier Universitaire de Clermont-Ferrand, 
      Clermont-Ferrand, France.
FAU - Baud, O
AU  - Baud O
FAU - Lesens, O
AU  - Lesens O
FAU - Delmas, J
AU  - Delmas J
FAU - Souweine, B
AU  - Souweine B
FAU - Traore, O
AU  - Traore O
LA  - eng
PT  - Journal Article
DEP - 20080709
PL  - Germany
TA  - Eur J Clin Microbiol Infect Dis
JT  - European journal of clinical microbiology & infectious diseases : official 
      publication of the European Society of Clinical Microbiology
JID - 8804297
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (DNA, Bacterial)
RN  - 61036-62-2 (Teicoplanin)
SB  - IM
MH  - Anti-Bacterial Agents/pharmacology
MH  - Bacterial Typing Techniques
MH  - Cluster Analysis
MH  - Cross Infection/*epidemiology/*microbiology
MH  - DNA Fingerprinting
MH  - DNA, Bacterial/genetics
MH  - *Disease Outbreaks
MH  - Drug Resistance, Bacterial
MH  - Electrophoresis, Gel, Pulsed-Field
MH  - Enterococcus faecium/classification/*drug effects/genetics/isolation & 
      purification
MH  - France/epidemiology
MH  - Genotype
MH  - Gram-Positive Bacterial Infections/*epidemiology/*microbiology
MH  - Hospitals, University
MH  - Humans
MH  - Infection Control/methods
MH  - Teicoplanin/pharmacology
MH  - *Vancomycin Resistance
EDAT- 2008/07/10 09:00
MHDA- 2009/02/14 09:00
CRDT- 2008/07/10 09:00
PHST- 2007/12/10 00:00 [received]
PHST- 2008/04/28 00:00 [accepted]
PHST- 2008/07/10 09:00 [pubmed]
PHST- 2009/02/14 09:00 [medline]
PHST- 2008/07/10 09:00 [entrez]
AID - 10.1007/s10096-008-0544-0 [doi]
PST - ppublish
SO  - Eur J Clin Microbiol Infect Dis. 2008 Nov;27(11):1061-4. doi: 
      10.1007/s10096-008-0544-0. Epub 2008 Jul 9.