PMID- 18613417
OWN - NLM
STAT- MEDLINE
DCOM- 20081204
LR  - 20080710
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 55
IP  - 82-83
DP  - 2008 Mar-Apr
TI  - Genetic distinctions and clinical characteristics of type 1 autoimmune hepatitis 
      in Taiwan.
PG  - 605-8
AB  - BACKGROUND/AIMS: The genetic features in Eastern autoimmune hepatitis (AIH) 
      patients are seldom surveyed. Previous studies on the linking of human leukocyte 
      antigen (HLA) with AIH have highlighted the necessity of evaluating ethnically 
      homogeneous populations, but no investigation for Taiwanese patients has been 
      reported. This study aims to evaluate the HLA characteristics of Taiwanese AIH 
      patients. METHODOLOGY: Medical records of Taiwanese AIH patients (1990-2005) were 
      reviewed and the correlation of HLA alleles with disease susceptibility and 
      severity was surveyed. HLA typing was performed by polymerase chain reaction 
      amplification with sequence-specific primers. RESULTS: Unlike the Western 
      reports, HLA-A1, B8, and DR3 were not identified. The most frequently encountered 
      was A11 (48.6%). DR4 (35.1%) was less often found than that in Japanese and 
      Chinese series. As compared with Taiwanese normal controls, the frequency of B35 
      was significantly increased (18.9% vs. 5.4%, odds ratio = 4.072, Pc < 0.001). 
      B35-postitive patients also had higher pretreatment serum aminotransferase 
      concentrations. More of the patients were cholestatic and responded well to a 
      lower dose of prednisolone as compared with those reported in the Western 
      literature. CONCLUSIONS: HLA-B35 plays a distinct role in susceptibility and 
      severity of AIH in Taiwan. Racial genetic backgrounds may account for the 
      different results.
FAU - Huang, Hui-Chun
AU  - Huang HC
AD  - Division of Gastroenterology, Department of Medicine, Taipei Veterans General 
      Hospital, Taipei, Taiwan.
FAU - Wu, Jaw-Ching
AU  - Wu JC
FAU - Huang, Yi-Shin
AU  - Huang YS
FAU - Teh-Ia, Huo
AU  - Teh-Ia H
FAU - Lo, Jing-Chuan
AU  - Lo JC
FAU - Li, Chun-Ping
AU  - Li CP
FAU - Chang, Full-Young
AU  - Chang FY
FAU - Lee, Shou-Dong
AU  - Lee SD
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Female
MH  - HLA Antigens/*genetics
MH  - Hepatitis, Autoimmune/*diagnosis/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Taiwan
EDAT- 2008/07/11 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/07/11 09:00
PHST- 2008/07/11 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/07/11 09:00 [entrez]
PST - ppublish
SO  - Hepatogastroenterology. 2008 Mar-Apr;55(82-83):605-8.