PMID- 18613546
OWN - NLM
STAT- MEDLINE
DCOM- 20081204
LR  - 20080710
IS  - 0125-1562 (Print)
IS  - 0125-1562 (Linking)
VI  - 38
IP  - 6
DP  - 2007 Nov
TI  - Outcomes in HIV-infected patients on antiretroviral therapy with tuberculosis.
PG  - 1053-60
AB  - HIV-infected patients with active tuberculosis (TB) having CD4 counts < 100/mm3 
      and who were antiretroviral therapy (ART) naive were reviewed retrospectively to 
      determine the outcomes of their tuberculosis infection. All patients received ART 
      at or after receiving anti-TB treatment. Clinical manifestations, treatment 
      regimens and outcomes were analyzed. Of 101 patients, 62 (61.4%) completed TB 
      treatment. Of these, 53.2% were treated with a 6-month standard TB regimen, while 
      the rest were treated with prolonged TB regimens. The median interval between 
      anti-TB treatment and ART was 68 days (range: 0-381). Among the clinically cured 
      patients 66.1% received rifampin concomitantly with nevirapine, and 32.3% 
      received rifampin concomitantly with efavirenz. The treatment success rate was 
      75.6%, with a mortality rate of 6.1%. The risk factors for death were resistant 
      TB (p = 0.03) and poor compliance (p < 0.05). Seven point nine percent had 
      multi-drug resistant TB. Possible or probable immune reconstitution inflammatory 
      syndrome (IRIS) was seen in 15 cases (14.9%). No life-threatening IRIS was 
      reported, and it did not affect disease outcome (p = 0.5). A shorter time between 
      anti-TB treatment and ART onset was associated with the occurrence of IRIS (31 
      days vs 90 days; p < 0.05). Regarding adverse drug effects, 44.6% had side 
      effects due either to anti-TB drugs or ART. Sixty-six point one percent of them 
      occurred within the first 2 months of TB treatment, and 43 (76.8%) had to stop or 
      change either anti-TB treatment or ART. The mortality rate with TB and HIV on ART 
      was low and the occurrence of IRIS did not carry any additional mortality.
FAU - Tansuphasawadikul, Somsit
AU  - Tansuphasawadikul S
AD  - Bamrasnaradura Institute, Ministry of Public Health, Nonthaburi, Thailand.
FAU - Saito, Wakana
AU  - Saito W
FAU - Kim, Jerome
AU  - Kim J
FAU - Phonrat, Benjaluck
AU  - Phonrat B
FAU - Dhitavat, Jittima
AU  - Dhitavat J
FAU - Chamnachanan, Supat
AU  - Chamnachanan S
FAU - Pitisuttithum, Punnee
AU  - Pitisuttithum P
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Southeast Asian J Trop Med Public Health
JT  - The Southeast Asian journal of tropical medicine and public health
JID - 0266303
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Adult
MH  - Anti-Retroviral Agents/*therapeutic use
MH  - Female
MH  - HIV Infections/*drug therapy/mortality/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Thailand/epidemiology
MH  - Treatment Outcome
MH  - *Tuberculosis/drug therapy
EDAT- 2008/07/11 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/07/11 09:00
PHST- 2008/07/11 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/07/11 09:00 [entrez]
PST - ppublish
SO  - Southeast Asian J Trop Med Public Health. 2007 Nov;38(6):1053-60.