PMID- 18614020
OWN - NLM
STAT- MEDLINE
DCOM- 20080725
LR  - 20220409
IS  - 1097-4172 (Electronic)
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 134
IP  - 1
DP  - 2008 Jul 11
TI  - Distinct role of long 3' UTR BDNF mRNA in spine morphology and synaptic 
      plasticity in hippocampal neurons.
PG  - 175-87
LID - 10.1016/j.cell.2008.05.045 [doi]
AB  - The brain produces two brain-derived neurotrophic factor (BDNF) transcripts, with 
      either short or long 3' untranslated regions (3' UTRs). The physiological 
      significance of the two forms of mRNAs encoding the same protein is unknown. 
      Here, we show that the short and long 3' UTR BDNF mRNAs are involved in different 
      cellular functions. The short 3' UTR mRNAs are restricted to somata, whereas the 
      long 3' UTR mRNAs are also localized in dendrites. In a mouse mutant where the 
      long 3' UTR is truncated, dendritic targeting of BDNF mRNAs is impaired. There is 
      little BDNF in hippocampal dendrites despite normal levels of total BDNF protein. 
      This mutant exhibits deficits in pruning and enlargement of dendritic spines, as 
      well as selective impairment in long-term potentiation in dendrites, but not 
      somata, of hippocampal neurons. These results provide insights into local and 
      dendritic actions of BDNF and reveal a mechanism for differential regulation of 
      subcellular functions of proteins.
FAU - An, Juan Ji
AU  - An JJ
AD  - Department of Pharmacology, Georgetown University, Washington, DC 20057, USA.
FAU - Gharami, Kusumika
AU  - Gharami K
FAU - Liao, Guey-Ying
AU  - Liao GY
FAU - Woo, Newton H
AU  - Woo NH
FAU - Lau, Anthony G
AU  - Lau AG
FAU - Vanevski, Filip
AU  - Vanevski F
FAU - Torre, Enrique R
AU  - Torre ER
FAU - Jones, Kevin R
AU  - Jones KR
FAU - Feng, Yue
AU  - Feng Y
FAU - Lu, Bai
AU  - Lu B
FAU - Xu, Baoji
AU  - Xu B
LA  - eng
GR  - R01 NS050596-03/NS/NINDS NIH HHS/United States
GR  - R01 NS050596/NS/NINDS NIH HHS/United States
GR  - R01 NS050596-02/NS/NINDS NIH HHS/United States
GR  - R01 NS050596-01A1S1/NS/NINDS NIH HHS/United States
GR  - NS050596/NS/NINDS NIH HHS/United States
GR  - R56 NS050596/NS/NINDS NIH HHS/United States
GR  - R01 NS050596-01A1/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (3' Untranslated Regions)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - 3' Untranslated Regions/*analysis/*metabolism
MH  - Animals
MH  - Dendrites/chemistry
MH  - Hippocampus/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neurons/chemistry/cytology/*metabolism
MH  - Polyadenylation
MH  - Protein Biosynthesis
MH  - Receptor, trkB/analysis/*genetics/*metabolism
PMC - PMC2527207
MID - NIHMS59763
EDAT- 2008/07/11 09:00
MHDA- 2008/07/26 09:00
PMCR- 2009/07/11
CRDT- 2008/07/11 09:00
PHST- 2007/05/10 00:00 [received]
PHST- 2008/03/26 00:00 [revised]
PHST- 2008/05/16 00:00 [accepted]
PHST- 2008/07/11 09:00 [pubmed]
PHST- 2008/07/26 09:00 [medline]
PHST- 2008/07/11 09:00 [entrez]
PHST- 2009/07/11 00:00 [pmc-release]
AID - S0092-8674(08)00708-3 [pii]
AID - 10.1016/j.cell.2008.05.045 [doi]
PST - ppublish
SO  - Cell. 2008 Jul 11;134(1):175-87. doi: 10.1016/j.cell.2008.05.045.